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Salutary Actions of Nicergoline During Experimental Coronary Artery Occlusion and Reperfusion

  • R. Bolli

Abstract

Recently, much attention has focussed on the possible beneficial effects of a-adrenergic-blocking agents in acute myocardial ischaemia. Prazosin and phentolamine prevent ventricular fibrillation induced by coronary artery occlusion and reperfusion in cats [1], although they fail to do so in dogs [2]. Minor antiarrhythmic effects of phentolamine have been reported in patients with acute myocardial infarction [3]. More importantly, afterload reduction by phentolamine has been shown to improve haemodynamics in the setting of acute myocardial infarction complicated by left ventricular failure and/or hypertension [4–6]. However, since phentolamine may incresae heart rate [5, 6], its effect on severity of ischaemia remains uncertain [7]. We [2] have previously shown that phentolamine and prazosin fail to improve severity of ischaemia (estimated from intramyocardial C02 tension), coronary collateral blood flow and arrhythmias during acute coronary occlusion in dogs.

Keywords

Ventricular Tachycardia Coronary Occlusion Aortic Pressure Ergot Alkaloid Coronary Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • R. Bolli
    • 1
  1. 1.Experimental Animal Laboratory, Cardiology SectionBaylor College of MedicineHoustonUSA

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