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Proof of Therapeutical Effectiveness of Nootropic and Vasoactive Drugs pp 133–147Cite as

Salutary Actions of Nicergoline During Experimental Coronary Artery Occlusion and Reperfusion

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Abstract

Recently, much attention has focussed on the possible beneficial effects of a-adrenergic-blocking agents in acute myocardial ischaemia. Prazosin and phentolamine prevent ventricular fibrillation induced by coronary artery occlusion and reperfusion in cats [1], although they fail to do so in dogs [2]. Minor antiarrhythmic effects of phentolamine have been reported in patients with acute myocardial infarction [3]. More importantly, afterload reduction by phentolamine has been shown to improve haemodynamics in the setting of acute myocardial infarction complicated by left ventricular failure and/or hypertension [4–6]. However, since phentolamine may incresae heart rate [5, 6], its effect on severity of ischaemia remains uncertain [7]. We [2] have previously shown that phentolamine and prazosin fail to improve severity of ischaemia (estimated from intramyocardial C02 tension), coronary collateral blood flow and arrhythmias during acute coronary occlusion in dogs.

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Authors and Affiliations

  1. Experimental Animal Laboratory, Cardiology Section, Baylor College of Medicine, 6535 Fannin, M.S. F905, Houston, TX, 77030, USA

    R. Bolli (Director)

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  1. R. Bolli
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Editors and Affiliations

  1. Innere Abteilung, Franziskus-Krankenhaus, Burggrafenstraße 1, D-1000, Berlin 30, Germany

    Heinz Heidrich

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© 1986 Springer-Verlag Berlin Heidelberg

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Bolli, R. (1986). Salutary Actions of Nicergoline During Experimental Coronary Artery Occlusion and Reperfusion. In: Heidrich, H. (eds) Proof of Therapeutical Effectiveness of Nootropic and Vasoactive Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70786-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-70786-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15901-8

  • Online ISBN: 978-3-642-70786-5

  • eBook Packages: Springer Book Archive

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