Einsatz stoffwechselsenkender Hypnotika beim Schädelhirntrauma

  • K. Wiedemann
  • H. Polarz


Bereits im Jahre 1937 wurde durch Horsley bekanntgemacht, daß Barbiturate den lumbalen Liquordruck vermindern.


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  1. 1.
    Abramson NS, Safar P, Detre K, Kelsey S, Monroe J, Reinmuth O, Snyder J, Mullie A, Hedstrand U, Tammisto T, Lund I, Breivik H, Lind B, Jastremski M (1983) Results of a randomized clinical trial of brain resuscitation with Thiopental. Anesthesiology 59: A101.Google Scholar
  2. 2.
    Arnfred J, Secher O (1962) Anoxia and barbiturates: tolerance to anoxia in mice influenced by barbiturates. Arch int Pharmacodyn 139: 67.Google Scholar
  3. 3.
    Astrup J, Skovsted P, Gjerris F, Sørensen HR (1981) Increase in extracellular potassium in the brain during circulatory arrest: effects of hypothermia, lidocaine and thiopental. Anesthesiology 55: 256.PubMedCrossRefGoogle Scholar
  4. 4.
    Bleyaert AL, Nemoto EM, Safar P, Stezoski SW, Mickell JJ, Moossy J, Rao GR (1978) Thiopental amelioration of brain damage after global ischemia in monkeys. Anesthesiology 49: 390.PubMedCrossRefGoogle Scholar
  5. 5.
    Branston NM, Hope DT, Symon L (1979) Barbiturates in focal ischemia of primate cortex: effects on blood flow distribution, evoked potentials and extracellular potassium. Stroke 10: 647.PubMedCrossRefGoogle Scholar
  6. 6.
    Bricolo AP, Glick RP (1981) Barbiturate effects on acute experimental intracranial hypertension. J. Neurosurg. 55: 397.CrossRefGoogle Scholar
  7. 7.
    Brock M, Wiegand H, Zillig C, Zynietz C, Mock P, Dietz H (1976) The effect of dexamethasone on intracranial pressure in patients with supratentorial tumors. In: Pappius HM, Feindel W (eds): Dynamics of brain oedema. Springer, Berlin-Heidelberg-New York 330.CrossRefGoogle Scholar
  8. 8.
    Bruce DA, Raphaely RA, Swerdlow D, Schut L (1980) The effectiveness of iatrogenic barbiturate coma in controlling increased ICP in 61 children. In: Intracranial pressure IV, pp 630–632. Shulman K, Marmarou A, Miller JD, Becker DP, Hochwald GM, Brock M (eds). Springer, Berlin-Heidelberg-New York.CrossRefGoogle Scholar
  9. 9.
    Demopoulos HB, Flamm ES, Seligman ML, Ransohoff J, Jorgensen E (1977) Antioxidant effects of barbiturates in model membranes undergoing free radical damage. Acta neurol scand 56, Suppl 64: 152.Google Scholar
  10. 10.
    Di Polo R, Beauge R (1979) Physiological role of ATP-driven calcium pump in squid axon. Nature 278: 271.CrossRefGoogle Scholar
  11. 11.
    Feustel PJ, Ingvar MC, Severinghaus JW (1981) Cerebral oxygen availability and blood flow during middle cerebral artery occlusion: Effects of pentobarbital. Stroke 12: 858.PubMedCrossRefGoogle Scholar
  12. 12.
    Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J (1978) Free radicals in cerebral ischemia. Stroke 9: 445.PubMedCrossRefGoogle Scholar
  13. 13.
    Gisvold SE, Safar P, Hendrickx HHL, Rao G, Moossy J, Alexander H (1984) Thiopental treatment after global brain ischemia in pigtailed monkeys. Anaesthesiology 60: 88.CrossRefGoogle Scholar
  14. 14.
    Harris RA (1981) Ethanol and pentobarbital inhibition of intrasynaptosomal sequestration of calcium. Biochem Pharmacol 30: 3209.PubMedCrossRefGoogle Scholar
  15. 15.
    Horsley JS (1937) The intracranial pressure during barbital narcosis. Lancet 1: 141.CrossRefGoogle Scholar
  16. 16.
    Hossmann KA (1982) Treatment of experimental cerebral ischemia. J Cereb Blood Flow Metabol 2: 275.CrossRefGoogle Scholar
  17. 17.
    Langfitt TW, Weinstein JD, Kassell NF (1965) Cerebral vasomotor paralysis produced by intracranial hypertension. Neurology 15: 622.PubMedGoogle Scholar
  18. 18.
    Marshall LF, Smith RW, Shapiro HM (1979) The outcome with aggressive treatment in severe head injuries. Part II. Acute and chronic barbiturate administration in the management of head injury. J Neurosurg 50: 26.PubMedCrossRefGoogle Scholar
  19. 19.
    McIlhany M, Rapaport R, Dunn R, Namazie M, Delilikan A (1983) Althesin in the management of head injuries: a preliminary report. Neurosurgery 12: 77.PubMedCrossRefGoogle Scholar
  20. 20.
    Miller JD, Becker DP, Child DC, Carmichael GLM (1984) Barbiturates in the management of severe head injury. Br J Anaesth 1313 P.Google Scholar
  21. 21.
    Miller JD, Butterworth JF, Gudeman SA, Faulkner JE, Choi SC, Seihorst JB, Harbison JW, Lutz HA, Young HF, Becker DP (1981) Further experience in the management of severe head injury. J Neurosurg 54: 289.PubMedCrossRefGoogle Scholar
  22. 22.
    Nilsson B, Nordström CH (1977) Rate of cerebral energy consumption in concussive head injury in the rat. J Neurosurg 47: 274.PubMedCrossRefGoogle Scholar
  23. 23.
    Overgaard J, Tweed WA (1983) Cerebral circulation after head injury. J Neurosurg 59: 439.PubMedCrossRefGoogle Scholar
  24. 24.
    Prior GJL, Hinds CJ, Williams J, Prior PF (1983) The Use of Etomidate in the management of severe head injury. Intens Care Med 9: 313.CrossRefGoogle Scholar
  25. 25.
    Rea GL, Rockswold GL (1983) Barbiturate therapy in uncontrolled intracranial hypertension. Neurosurgery 12: 401.PubMedCrossRefGoogle Scholar
  26. 26.
    Saul TG, Ducker TB (1982) Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. J Neurosurg 56: 489.Google Scholar
  27. 27.
    Sehested P, Fedders O, Tange M, Overgaard J (1976) Does barbiturate “monotherapy“ favourably influence brain survival after traumatic coma? In: Jensen HP, Brock M, Klinger M (eds): Dynamics of brain oedema. Springer, Berlin-Heidelberg-New York, 330.Google Scholar
  28. 28.
    Selman WR, Spetzler F, Roski A, Roessmann U, Crumrine R, Macko R (1982) Barbiturate coma in focal cerebral ischemia. Relationship of protection to timing of therapy. J Neurosurg 56: 685.PubMedCrossRefGoogle Scholar
  29. 29.
    Shiu GK, Nemmer JP, Nemoto EM (1983) Reassessment of brain free fatty acid liberation during global ischemia and its attenuation by barbiturate anaesthesia. J. Neurochemistry 40: 880.CrossRefGoogle Scholar
  30. 30.
    Simeone FA, Frazer G, Lawner P (1979) Ischemic brain oedema: comparative effects of barbiturates and hypothermia. Stroke 19: 8.CrossRefGoogle Scholar
  31. 31.
    Smith AL, Marque JJ (1976) Anesthetics and cerebral oedema. Anaesthesiology 45: 64.CrossRefGoogle Scholar
  32. 32.
    Smith DS, Rehncrona S, Siesjö BK (1980) Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro. Comparison with the effects of promethazine and chlorpromazine. Anesthesiology 53: 180.CrossRefGoogle Scholar
  33. 33.
    Spetzler RF, Selman WR, Roski RA, Bonstelk CB (1982) Cerebral revascularization during barbiturate coma in primates and humans. Surg Neurol 17: 111.PubMedCrossRefGoogle Scholar
  34. 34.
    Willow M, Bygrave FL (1982) Effects of pentobarbitone on 45Ca2+ transport by rat brain mitochondria. J. Neurochem 39: 557.PubMedCrossRefGoogle Scholar
  35. 35.
    Yasuda H, Shimada O, Nakajima A, Asano T (1981) Cerebral protective effect and radical scavenging action. J Neurochem 37: 934.PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • K. Wiedemann
  • H. Polarz

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