The effect of subinhibitory concentrations of monobactams on bactericidal activity of macrophages
It has been demonstrated that subminimum inhibitory concentrations (sub-MICs) of antibiotics have some effects on bacterial growth rate and morphology . In other studies, it has been shown that sub-MICs of antibiotics alter adhesiveness of bacteria to mucosal surfaces  and enhance the bactericidal activity of human polymorphonuclear-leukocytes [1,10,11]. In addition to chemotherapy, host-defence reactions are important to host resistance against microbial infection. It is not fully understood how sub-MICs of antibiotics influence interactions between bacteria and the human host. We have been studying the effect of sub-MICs of antibiotics on such interactions, and found that monobactams, monocyclic β-lactam antibiotics (Aztreonam and AMA1080) potentiate the bactericidal activity of macrophages. Thus, monobactams may be expected to be useful agents for the clinical treatment of bacterial infections.
KeywordsMinimum Inhibitory Concentration Hank Balance Salt Solution Bactericidal Assay Cross Wall Bactericidal Substance
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- 6.Georgopapadokou NH, Smith SA, Sykes RB (1982) Mode of action of azthreonam. Antimicrob Agents Chemother 21: 950–956Google Scholar
- 7.Leijh PCJ, Barselaar M, Zwet T, Dubbeldeman-Rempt I, Furth R (1978) Kinetics of phagocytosis of Staphylococcus aureus and Escherichia coli by human granulocytes. Immunol 37: 453–456Google Scholar
- 15.Zerigs BJ (1981) Bactericidal and fungicidal assay. In: Horscowitz H, Holden HT, Bellanti JA, Ghaffen A (eds) Manual of macrophage methodology. Marcel Dekker, New York and Basel, p 251Google Scholar