The effect of subinhibitory concentrations of monobactams on bactericidal activity of macrophages

  • K. Iida-Tanaka
  • T. Tanaka
  • S. Irino
  • A. Nagayama
Conference paper


It has been demonstrated that subminimum inhibitory concentrations (sub-MICs) of antibiotics have some effects on bacterial growth rate and morphology [8]. In other studies, it has been shown that sub-MICs of antibiotics alter adhesiveness of bacteria to mucosal surfaces [4] and enhance the bactericidal activity of human polymorphonuclear-leukocytes [1,10,11]. In addition to chemotherapy, host-defence reactions are important to host resistance against microbial infection. It is not fully understood how sub-MICs of antibiotics influence interactions between bacteria and the human host. We have been studying the effect of sub-MICs of antibiotics on such interactions, and found that monobactams, monocyclic β-lactam antibiotics (Aztreonam and AMA1080) potentiate the bactericidal activity of macrophages. Thus, monobactams may be expected to be useful agents for the clinical treatment of bacterial infections.


Minimum Inhibitory Concentration Hank Balance Salt Solution Bactericidal Assay Cross Wall Bactericidal Substance 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • K. Iida-Tanaka
    • 1
  • T. Tanaka
    • 1
  • S. Irino
    • 1
  • A. Nagayama
    • 2
  1. 1.1st Department of Internal MedicineKagawa Medical SchoolIkenobe, Miki, KagawaJapan
  2. 2.Department of MicrobiologySaga Medical SchoolNabeshima, SagaJapan

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