Advertisement

Indirect Antibiotic Effects on Granulocyte Migration and Phagocytosis

  • Håkan Gnarpe
  • Judy Belsheim
Conference paper

Abstract

It is well known that patients with low numbers of neutrophil granulocytes or with different mal-functions of neutrophil granulocytes [6] do become infected more easily and that infections tend to be more serious in these patients than in individuals with normal granulocytes [6].

Keywords

Antimicrob Agent Chemotactic Factor Neutrophil Granulocyte Fusidic Acid Betalactam Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Anderson OK, Volden G, Revhaug A, Lundgren TI, Giercksky K-E (1984) Lysosomal hydrolases in Neutrophils, Mononuclear Cells and Serum during Escherichia coli Endotoxemia in Pigs. Scand J Infect Dis 16: 349CrossRefGoogle Scholar
  2. 2.
    Bellashéne A, Forsgren AJ (1980) Effect of rifampin on the immune response in mice. Infect Imm 27: 15Google Scholar
  3. 3.
    Belsheim J (1981) A modified leukocyte migration under agarose technique (LMAT). Acta path mibrobiol scand Sect C 89: 167Google Scholar
  4. 4.
    Forsgren A, Schmeling D (1977) Effect of antibiotics on Chemotaxis of human leukocytes. Antimicrob Agents Chemother 11: 580PubMedGoogle Scholar
  5. 5.
    Forsgren A, Bacnk G, Beckman H, Bellashéne A (1980) Antibiotic-host defence interactions in vitro and in vivo. Scand J Infect Dis 24: 195Google Scholar
  6. 6.
    Gallin JI (1981) Anormal phagocyte Chemotaxis: pato-physiology, clinical manifestations and management of patients. Rev Infect Dis 3: 1196PubMedCrossRefGoogle Scholar
  7. 7.
    Gemmell CG (1984) Potentiation of phagocytosis of pathogenic bacteria by exposure to low concentrations of antibiotics (Leading article) J Antimicrob Chemother 13: 407Google Scholar
  8. 8.
    Gnarpe H, Belsheim J (1981) Direct and Indirect effects of antibiotics on granulocyte activity. J Antimicrob Chemother 8, Suppl. C. 71Google Scholar
  9. 9.
    Gnarpe H, Belsheim J, Blomqvist C, Lundbäck A (1984) Stimulation of Granulocyte Functions in Vitro by Imipenem and the Renal Enzyme Inhibitor MK 0791. Antimicrob Agents Chemother 25: 179PubMedGoogle Scholar
  10. 10.
    Gnarpe H, Belsheim J (1985) Interaction of Antibiotics with Granulocytes and Lymphocytes. Zbl Bakt Suppl 13, 123Google Scholar
  11. 11.
    Grant M, Raeburn JA, Sutherland R, Harkness RA, Gormley JP, Kowolik MJ (1983) Effect of two antibiotics on human granulocyte activities. J Antimicrob Chemother 11: 543PubMedCrossRefGoogle Scholar
  12. 12.
    Hed J (1977) The extinction of fluorescence by crystal violet and its use to differentiate between attached and ingested organisms in phagocytosis. FEMS Microbiol. Lett. 1: 357Google Scholar
  13. 13.
    Miller TE (1984) Host Defence Mechanisms, Antibiotics and Immunosuppressive Agents - A complex Relationship. (Editorial) Eur J Clin Microbiol 3: 285PubMedCrossRefGoogle Scholar
  14. 14.
    O’Brien J, Friedlander A, Dreier T, Ezzell J, Leppla S (1985) Effects of Anthrax Toxin Components on Human Neutrophils. Infect Imm 47: 306Google Scholar
  15. 15.
    Oleske JM (1984) Effects of antimicrobials on host defence mechanisms (Leading article) J Antimicrob Chemother 13: 413Google Scholar
  16. 16.
    Prokesh RC, Hand WL (1982) Antibiotic entry into human polymorphonuclear leukocytes. Antimicrob Agents Chemother 21: 373Google Scholar
  17. 17.
    Welch WD, Davis D, Thrupp LD (1981) Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function. Antimicrob Agents Chemother 20: 15PubMedGoogle Scholar
  18. 18.
    Yoshida T, Cohen S, Bigazzi PE, Kuraswij T, Amsden A (1975) Inflammatory mediators in culture filtrates of Escherichia coli. Amer. J. Path. 81: 389Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Håkan Gnarpe
    • 1
  • Judy Belsheim
    • 1
  1. 1.Department of Clinical BacteriologyGävle Central Hospital17 GävleSweden

Personalised recommendations