The Origin and Meiotic Instability of a Polymorphic Repetitive Sequence PRI Family
Genomic diversity within a given species has often been demonstrated by differences in electrophoretic mobilities of proteins and by DNA restriction site polymorphism (Giblet,1977; Arnheim and Southern, 1977; Jeffreys,1979). This is due to DNA sequence polymorphism. The genome size also seems to vary in different individuals, since the amount and distribution of centromeric heterochromatin, detected by chromosome banding techniques, vary in mice (Dev et al.,1973; Miller et al., 1976; Moriwaki and Minezawa, 1976; Yoshida and Kodama, 1983). A certain class of repetitive DNA is located in this chromosome region (Pardue and Gall, 1970; Jones, 1970). The polymorphic repetitive sequence PRI family (Kominami et al., 1983a) is of this type, because the copy number and fragment size of this family differ within mouse species and even in different inbred strains.
KeywordsRepetitive Sequence Space Region Synaptonemal Complex Centromeric Heterochromatin Unequal Crossover
Unable to display preview. Download preview PDF.
- Hilkens J., Hilgers J., Demant P., Michalides R., Ruddle F., Nichols E., Holmes R., van Nie R., Vandeberg J.L. and Nikkels R.(1981) Mammary tumours in the mouse. Hilgers J. and Sluyser M. eds., Elservier /North-Holland Boimedical Press, 11–44.Google Scholar
- Kominami R., Sudo K., Yoshikura H., Suzuki H., Moriwaki K., Hilgers J. and Muramatsu M. (1985) A polymorphic repetitive sequence PR1 family; Evidence for meiotic instability. J. Mol. Biol, in pressGoogle Scholar
- Moriwaki K. and Minezawa M.(1976). Geographical distribution of No. 18 chromosome polymorphism. Ann. Rep. Natl. Inst. Genet., 27, 46–47.Google Scholar