Studies into the raf and Rif Genes in the Mouse

  • V. Pachnis
  • A. Belayew
  • S. M. Tilghman
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


My laboratory has been interested in the mechanisms underlying the regulated expression of the murine albumin and α-fetoprotein (AFP) genes in the mouse. These genes are located on chromosome 5 in the mouse, with the 18 kilobase pair (Kb) long albumin gene 14 kb upstream of the 22 kb AFP gene (D’Eustachio et al 1981; Ingram et al 1981). Structural comparisons between the two genes in several species have unequivocably established their evolutionary relationship.


Visceral Endoderm Albumin Gene Autosomal Recessive Gene Fetal Mouse Liver High Stringency Hybridization 
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  1. Abelev GI (1971) Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors. Adv Cancer Res 14:295–358PubMedCrossRefGoogle Scholar
  2. Belayew A, Tilghman SM (1982) A Genetic Analysis of α-Fetoprotein Synthesis in the Mouse. Mol Cell Biol 2:1427–1435PubMedGoogle Scholar
  3. D’Eustachio P, Ingram, RS, Tilghman, SM, Ruddle, FH (1981) Murine α-Fetoprotein and Albumin: Two Evolutionary Linked Proteins Encoded on the same Mouse Chromosome. Somat Cell Genet 7:289–294PubMedCrossRefGoogle Scholar
  4. Ingram RS, Scott RW, Tilghman, SM (1981) The α-Fetoprotein and Albumin Genes are in Tandem in the Mouse Genome. Proc Natl Acad Sci USA 78:4694–4698PubMedCrossRefGoogle Scholar
  5. Kuhlman WD (1979) Immunoperoxidase Labelling of Alpha-Fetoprotein (AFP) in Normal and Regenerating Livers of a Low and a High AFP Producing Mouse Strain. Histochemistry 64:67–75CrossRefGoogle Scholar
  6. Olsson M, Lindahl G, Ruoslahti, E (1977) Genetic Control of Alpha-Fetoprotein Synthesis in the Mouse. J Exp Med 145:819–827PubMedCrossRefGoogle Scholar
  7. Pachnis V, Belayew A, Tilghman SM (1984) Locus Unlinked to a-Fetoprotein Under the Control of the Murine raf and Rif Genes. Proc Natl Acad Sci USA 81:5523–5527PubMedCrossRefGoogle Scholar
  8. Tilghman SM, Belayew A (1982) Transcriptional Control of the Murine Albumin: α-Fetoprotein Locus During Development. Proc Natl Acad Sci USA 79:5254–5257PubMedCrossRefGoogle Scholar
  9. Young PR, Tilghman SM (1984) Induction of α-Fetoprotein Synthesis in Differentiating F9 Teratocarcinoma Cells Is Accompanied by a Genome-Wide Loss of DNA Methyl ation. Mol Cell Biol 4:898–907PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • V. Pachnis
  • A. Belayew
  • S. M. Tilghman

There are no affiliations available

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