Studies into the raf and Rif Genes in the Mouse
My laboratory has been interested in the mechanisms underlying the regulated expression of the murine albumin and α-fetoprotein (AFP) genes in the mouse. These genes are located on chromosome 5 in the mouse, with the 18 kilobase pair (Kb) long albumin gene 14 kb upstream of the 22 kb AFP gene (D’Eustachio et al 1981; Ingram et al 1981). Structural comparisons between the two genes in several species have unequivocably established their evolutionary relationship.
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