Characteristics of the wm Substrain of BALB/c Mice

  • W. H. Murphy
  • G. L. Bolgos
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


Our substrain (Staats 1976) of BALB/cwm mice originated with MacDowell who provided it to Professor J.T. Syverton at The University of Minnesota,viz., the BALB/csy substrain. It is still maintained there by Professor D.W. Watson. The C58/sy substrain was obtained from MacDowell at the same time. The first major publication reporting the experimental use of the BALB/csy substrain dates to October 1952 (Werder 1953). The early pedigree records have been lost but I estimate that the BALB/c mice were obtained from MacDowell in 1950. I assumed responsibility for maintaining them as an inbred strain in 1952 when they were designated the BALB/cwm substrain. I moved both the BALB/cwm and C5 8/wm substrains to The University of Michigan in January of 1958. The BALB/cwm substrain at that time was at generations F-100 through F-104. The C58/wm strain was at generations Fill through F114. Both strains were renumbered at generation F1 when moved to Michigan so that they could be distinguished from the stocks left at Minnesota. Each of the strains has been maintained as separate closed colonies since 1952 and have not been directly exposed to other mice since then. They now are at F generations of approximately 350.


Natl Cancer Inst Inbred Strain Inbred Mouse Lymph Node Preparation Mycoplasma Fermentans 
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© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • W. H. Murphy
  • G. L. Bolgos

There are no affiliations available

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