Response of the Peritoneal Mesothelium to the Mineral Oil, Pristane

  • L. V. Leak
  • M. Potter
  • W. J. Mayfield
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


In searching for active chemical agents that would induce the formation of plasma cell tumors in BALB/Cπ mice, Potter and coworkers found that mineral oil and pure alkanes such as pristane were very effective in producing plasmacytomas when injected into the peritoneal cavity (Potter and MacCardle 1964, Anderson and Potter, 1969, Potter and Wax, 1981). The intraperitoneal injection of these substances evoked the formation of an oil granuloma on the visceral and parietal surfaces of the peritoneal cavity and provided an environment for development of plasma cell tumors. While this procedure is also used for obtaining immunoglobulin producing cells against a variety of antigens (Potter 1972), the structural basis for cellular aggregation and differentiation leading to the proliferation and focal collection of lymphoid cells on the peritoneal mesothelium is still unclear.


Mesothelial Cell Peritoneal Cell C57BL Mouse Cellular Aggregate Filamentous Network 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • L. V. Leak
  • M. Potter
  • W. J. Mayfield

There are no affiliations available

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