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Pristane-Induced Arthritis in BALB/c Mice

  • S. J. Hopkins
  • A. J. Freemont
  • M. I. V. Jayson
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)

Abstract

As part of a report on plasmacytoma incidence in sub-lines of Balb/c mice, Michael Potter and Judith Wax described an arthritis which occured in the fore and hind limbs of many of these animals (Potter and Wax 1981). The absence of good models for rheumatoid arthritis and the fact that the nature of arthritis induction seemed different to previous models suggested that this system was worth examining. The Balb/cJ sub-line was found to be the best responder for arthritis induction by Potter and Wax and this happened to be the background of the sub-line available in our animal facility (Balb/cJ/01a). The first few experiments indicated that we were getting a similar incidence of arthritis and a number of tissues were examined histologically. These initial findings have been reported (Hopkins, Freemont and Jayson 1984) and we have now completed further experiments, which extend and confirm our earlier findings.

Keywords

Hind Limb Neutrophil Infiltration Chronic Inflammatory Cell Clinical Arthritis Bone Marrow Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chang YH, Pearson CM, Abe C (1980) Adjuvent polyarthritis. IV Induction by a synthetic adjuvant: immunologic, histopathologic and other studies. Arthritis Rheum 13: 61–71.Google Scholar
  2. Hopkins SJ, Freemont AJ, Jayson MIV (1984) Pristane-induced arthritis in Balb/c mice. I Clinical and histologic features of the arthropathy. Rheumatol Int 5: 21–28PubMedCrossRefGoogle Scholar
  3. Potter M, Wax JS (1981) Genetics of susceptibility to pristane- induced plasmacytomas in Balb/cAn: reduced susceptability in Balb/cJ with a brief description of pristane-induced arthritis. J Immunol 127: 1591–1595PubMedGoogle Scholar
  4. Wilner BI, Evers MA, Troutman HD, Trader FW and McLean IW Jr. (1963). Vaccine potentiation by emulsification with pure hydrocarbon compounds. J. Immunol 91: 210–229.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • S. J. Hopkins
  • A. J. Freemont
  • M. I. V. Jayson

There are no affiliations available

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