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Isotype-Specific Interactions Between Regulatory T Cells and Secreted and Membrane-Bound Monoclonal Immunoglobulins

  • R. G. Lynch
  • A. Mathur
  • K. R. Williams
  • A. Mueller
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)

Abstract

Previous studies have established that elements of the immunoregulatory system of the mouse can be directed to plasmacytoma cells in vivo and in vitro and influence their growth, differentiation and immunoglobulin expression. Those studies, which have been reviewed elsewhere (Lynch, 1979), have shown that certain murine plasmacytomas can respond to antigen-specific and idiotype-specific helper and suppressor T cells.

Keywords

Splenic Lymphocyte Monoclonal Immunoglobulin Plasmacytoma Cell Immunoregulatory System Immunoglobulin Heavy Chain Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Gebel HM, Hoover RG, Lynch RG (1979) Lymphocyte surface membrane immunoglobulin in myeloma. I. M315-bearing T lymphocytes in mice with MOPC-315. J Immunol 123:1110–1116PubMedGoogle Scholar
  2. Hoover RG, Dieckgraefe BK, Lake J, Kemp JD, Lynch RG (1982) Lymphocyte surface membrane immunoglobulin in myeloma. III. IgA plasmacytomas induce large numbers of circulating, adult-thymectomy-sensitive, θ+, Lyt 1 2+ lymphocytes with IgA-Fc receptors. J Immunol 129:2329–2331PubMedGoogle Scholar
  3. Hoover RG, Dieckgraefe BK, Lynch RG (1981) T cells with Fc receptors for IgA: Induction of Ta cells in vivo and in vitro by purified IgA. J Immunol 127:1560–1563PubMedGoogle Scholar
  4. Hoover RG, Lynch RG (1980) Lymphocyte surface membrane immunoglobulin in myeloma. II. T cells with IgA-Fc receptors are markedly increased in mice with IgA plasmacytomas. J Immunol 125:1280–1285PubMedGoogle Scholar
  5. Hoover RG, Lynch RG (1982) T cells with Fc receptors for IgA: C3H/HeJ mice have elevated numbers of T cells in GALT but are deficient in T cells and T cell precursors in spleen. Fed Proc 41:839Google Scholar
  6. Hoover RG, Lynch RG (1983) Isotype-specific suppression of IgA: Suppression of IgA responses in BALB/c mice by Ta cells. J Immunol 130:521–523PubMedGoogle Scholar
  7. Lynch RG, Rohrer JW, Odermatt B, Gebel HM, Autry JR, Hoover RG (1979) Immunoregulation of Murine Myeloma Cell Growth and Differentiation: A Monoclonal Model of B Cell Differentiation. Immunological Rev 48:45–80CrossRefGoogle Scholar
  8. Mathur A, Mackawa S, Ovary Z, Lynch RG (to be published) IgE-secreting hybridomas induce marked expansion of T cells. Fed ProcGoogle Scholar
  9. Milburn GL, Lynch RG (1982) Immunoregulation of murine myeloma in vitro. II. Suppression of MOPC-315 immunoglobulin secretion and synthesis by idiotype-specific suppressor T cells. J Exp Med 155:852–861PubMedCrossRefGoogle Scholar
  10. Muller S, Hoover RG (1985) T cells with Fc receptors in myeloma: Suppression of growth and secretion of MOPC-315 by Ta cells. J Immunol 134:644–647PubMedGoogle Scholar
  11. Spiegelberg HL (1984) Structure and function of Fc receptors for IgE on lymphocytes, monocytes and macrophages. Adv Immunol 35:61PubMedCrossRefGoogle Scholar
  12. Williams KR, Lynch RG (1984) A clonal model for T lymphocytes bearing Fc receptors for IgA. Fed Proc 43:1970Google Scholar
  13. Xue B, Coico R, Wallace D, Siskind GW, Pernis B, Thorbecke GJ (1984) Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD-secreting plasmacytomas. J Exp Med 159:103–113PubMedCrossRefGoogle Scholar
  14. Yodoi J, Adachi M, Teshigawara K, Masuda M, Fridman W (1983) T cell hybridomas co-expressing Fc receptors (FcR) for different isotypes. J Immunol 131:303–310PubMedGoogle Scholar
  15. Zolla-Pazner S (1980) Immunodeficiency induced by plasma cell tumors: Comparison of findings in human and murine hosts. In: Potter (ed) Progress in Myeloma. Elsevier North Holland, Inc p 171–184Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. G. Lynch
  • A. Mathur
  • K. R. Williams
  • A. Mueller

There are no affiliations available

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