Advertisement

Differential Susceptibility to Experimental Autoimmune Orchitis in BALB/c Substrains

  • C. Teuscher
  • M. Potter
  • K. S. K. Tung
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)

Abstract

Experimental allergic orchitis (EAO) is an organ specific autoimmune disease which can be readily induced in a susceptible mouse strain by a single injection of mouse testicular homogenate (MTH) emulsified in complete Freund’s adjuvant with either Bordetella pertussis organisms (Pokorna et al 1963; Bohme 1965; Hargis et al 1968; Bernard et al 1978; Sato et al 1981) or an extract enriched in pertussigen prepared from the spent media of B. pertussis cultures (Kohno et al 1983). Murine EAO is manifest as inflammation in the testis (orchitis), epididymitis, and vasitis (Kohno et al 1983). The histopathologic evidence of autoimmune orchitis first appears 10–15 days after immunization with maximal disease involvement occurring by day 20–25. Testicular lesions are characterized by varying degrees of interstitial, peritubular, and intratubular infiltration of eosinophils, neutrophils, lymphocytes, and macrophages. In severe disease, global necrosis may be seen. In the seminiferous tubules desquamation of germ cells leading to aspermatogenesis occurs concomitantly with the development of autoimmune orchitis.

Keywords

Bordetella Pertussis Dominant Autosomal Trait Major Histocompatability Complex Organ Specific Autoimmune Disease Intermediate Susceptibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baily DW (1978) Sources of subline divergence and their relative importance for sublines of six major inbred strains of mice. In: Morse III HC (ed) Origins of inbred mice, Academic Press, New York, p. 197.Google Scholar
  2. Bernard CCA, Mitchell GF, Leydon J, Bargerbos A (1978) Experimental autoimmune orchitis in T cell-deficient mice. Int Arch Allerg Appl Immunol 56: 256.CrossRefGoogle Scholar
  3. Bohme D (1965) Experimentelle allergische orchitis und reticuloendotheliales system. II. Histologische Veränderungen. Immun and Allerg Forsch 128: 31.Google Scholar
  4. Ciaranello RD, Axelrod J (1973) Genetic controlled alterations in the rate of degradation of phenylethanolamine N-methyltransferase. J Biol Chem 248: 5616.PubMedGoogle Scholar
  5. Ciarenello RD, Hoffman HJ, Shire JGM, Axelrod J (1974) Genetic regulation of the catecholamine biosynthetic enzymes. II. Inheritence of tyrosine hydroxylase, dopamine B-hydroxylase and phenylethanolamine N-methyl transferase. J Biol Chem 249: 4528.Google Scholar
  6. Ciaranello RD, Lipsky A, Axelrod J (1974) Association between fighting behavior and catecholamine biosynthetic enzyme activity in two inbred mouse strains. Proc Natl Acad Sci 71: 3006.PubMedCrossRefGoogle Scholar
  7. David CS (1984) H-2 regulation of autoimmune and infection diseases. In: Sasazuki T, Tada T (eds) Immunogenetics: Its application to clinical medicine, Academic Press, New York, p 63.Google Scholar
  8. Demant P, Ivanyi D, Oudshoorn-Snoek M, Calatat J, Roos MH (1981) Molecular heterogeneity of H-2 antigens. Immunol Rev 60: 5.PubMedCrossRefGoogle Scholar
  9. Forman J, Flaherty L (1978) Identification of a new CML target antigen controlled by a gene associated with the Qa-2 locus. Immunogenetics 6: 227.CrossRefGoogle Scholar
  10. Goodenow RS, McMillan M, Nicolson J, Sher BT, Eakle K, Davidson N, Hood L (1982) Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature (London) 300: 231.CrossRefGoogle Scholar
  11. Hargis BJ, Malkeil S, Berkeha J, (1968) Immunologically induced aspermatogenesis in the white mouse. J Immunol 101: 374.PubMedGoogle Scholar
  12. Kohno S, Munoz JA, Williams TS, Teuscher C, Bernard CCA, Tung KSK (1983) Immunopathology of murine experimental allergic orchitis. J Immunol 130: 2675.PubMedGoogle Scholar
  13. Lillehoj EP, Hansen TH, Sachs DH, Coligan JE (1984) Primary structural evidence that the H-2Dq region encodes at least three distinct gene products: Dq, Lq, and Rq. Proc Natl Acad Sci 81: 2499.PubMedCrossRefGoogle Scholar
  14. Olsson MG, Lindahl G, Ruoslahti E (1977) Genetic control of alpha-fetoprotein synthesis in the mouse. J Exp Med 145: 819.PubMedCrossRefGoogle Scholar
  15. Ovary Z, Vris TW, De Szalay C, Vaz NM, Iritani C (1973) Independent segregation of the H-2 locus for responsiveness to histamine-sensitizing factor. Proc Natl Acad Sci 70: 2500.PubMedCrossRefGoogle Scholar
  16. Porkorna Z, Vojtiskova M, Rychlikova M, Chutna J (1963) An isologous model of experimental autoimmune aspermatogenesis in the mouse. Folia Biol 9: 203.Google Scholar
  17. Potter M, Wax JS (1981) Genetics of susceptibility to pristane-induced plasmacytomas in BALB/c An: Reduced susceptibility in BALB/c J with a brief description of pristane-induced arthritis. J Immunol 127: 1591.PubMedGoogle Scholar
  18. Sato K, Hirokawa K, Hatakeyama S (1981) Experimental allergic orchitis in mice. Virchow Arch (Pathol Anat) 392: 147.CrossRefGoogle Scholar
  19. Teuscher C, Smith SM, Goldberg, EH, Shearer GM, Tung KSK (1985) Experimental allergic orchitis in mice: I. Genetic control of susceptibility and resistance to induction of autoimmune orchitis. Immunogenetics (in press).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • C. Teuscher
  • M. Potter
  • K. S. K. Tung

There are no affiliations available

Personalised recommendations