Abstract
The differential susceptibilities of inbred mice to tumor development have provided systems to study some of the host cell genes that control these complex processes. In the case of genes that control susceptibility to exogenous tumor viruses several levels of host susceptibility are possible. These include infection of appropriate tissues, transformation of susceptible tissues, and immunological responses to infected or transformed cells. Although there is evidence that each may be the basis of action for some host susceptibility genes; in no case is there sufficient evidence for molecular models of how host susceptibility genes work.
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References
Abelson HT, Rabstein LS (1970) Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer Res 30:2213–2222
Bailey DW (1971) Recombinant inbred strains: an aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11:325
Cook W (1982) Rapid thymomas induced by Abelson murine leukemia virus. Proc Natl Acad Sci USA 79:2917–2921
Cook W (1985) Thymocyte subsets transformed by Abelson murine leukemia virus. Mol Cell Biol 5:390–397
Corcoran L, Adams JM, Dunn AR, Cory S (1984) Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 37:113–122
Fischinger PJ, Nomura S, Bolognesi D (1975) A novel murine oncornavirus with dual eco-and xenotropic properties. Proc Natl Acad Sci USA 72:5150–5155
Gisselbrecht S, Pozo F, Debre P, Hurot MA, Lacombe MJ, Levy JP (1978) Genetic control of sensitivity to Moloney virus induced leukemias in mice, demonstration of multigenic control. Int J Cancer 21:626–632
Goff S, Gilboa E, Witte 0, Baltimore D (1980) Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell 22: 777–785
Green PG, Lamph WW, Dudley J, Arfsten A, Risser R, Lanier L, Warner NL, Tung JT, Scheid MP (1985) Phenotypic variation in clonal Abelson virus lymphoma cells. J Immunol 134:1268–1275
Pepersack L, Lee JC, McEwan R, and Ihle JN (1980) Phenotypic heterogeneity of Moloney leukemia virus induced T cell lymphoma. J Immunol 124:279–285
Pillemer E, Whitlock C, Weissman I (1984) Transformation-associated proteins in murine B-cell lymphomas that are distinct from Abelson virus gene products. Proc Natl Acad Sci USA 81:4434–4438
Potter M, Sklar MD, Rowe WP (1973) Rapid viral induction of plasmacytomas in pristine-primed BALB/c mice. Science (Wash DC) 182:592
Premkumar E, Potter M, Singer PA, Sklar M (1975) Synthesis, surface deposition, and secretion of immonoglobulins by Abelson virus- transformed lymphosarcoma cell lives. Cell 6:149–159
Reddy EP, Smith MJ, Srinivasan A (1983) Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other one gene products with tyrosine-specific kinase activity. Proc Natl Acad Sci USA 0:3623–3627
Reynolds FH, Sacks TL, Deobagkar DN, Stephenson JR (1978) Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components. Proc Natl Acad Sci USA 75:3974–3978
Risser R, Potter M, Rowe WP (1978) Abelson Virus-induced Lymphomagenesis in mice. J Exp Med 148:714–726
Risser R, Stockert E, Old LJ (1978) Abelson antigen: A viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci USA 75:3918–3922
Risser R (1982) The pathogenesis of Abelson virus lymphomas of the mouse. Biochem Biophys Acta 651:213–244
Rosenberg N, Baltimore D (1976) A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med 143:14 53–1463
Rosenberg N, Baltimore D (1978) The effect of helper virus on Abelson virus-induced transformation of lymphoid cells. J Exp Med 147:1126–1147
Rosenberg N, Clark D, Witte O (1980) Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation. J Virol 36:766–744
Scher CD (1978) Effect of pseudotype on Abelson virus and Kirsten sarcoma virus-induced leukemia. J Exp Med 147:1044–1053
Scher CD, Siegler R (1975) Direct transformation of 3T3 cells by Abelson murine leukemia virus. Nature (Lond) 253:729
Selten G, Cuypers HT, Zijlstra M, Melief C, Berns A (1984) Involvement of c-myc in MuLV-induced T-cell lymphomas in mice: frequency and mechanisms of activation. EMBO J 3:3215–3222
Sklar MD, Shevach EM, Green I, Potter M (1975) Transplantation and preliminary characterization of lymphocyte surface markers of Abelson virus-induced lymphoma. Nature (Lond) 253:550
Vogt M (1979) Properties of “mink cell focus-inducing” (MCF) virus isolated from spontaneous lymphoma lines of BALB/c mice carrying Moloney leukemia virus as an endogenous virus. Virology 93:226–236
Wang JYJ, Ledley F, Goff S, Lee R, Groner Y, Baltimore D (1984) The mouse c-abl locus: molecular cloning and characterization. Cell 36:349–356
Watanabe SM, Rosenberg NE, Witte ON (1984) A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitro. J Virol 51:620–627
Witte ON, Goff S, Rosenberg N, Baltimore D (1980) A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. Proc Natl Acad Sci USA 77:4993–4997
Witte ON, Rosenberg N, Paskind M, Shields A, Baltimore D (1978) Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci USA 75:2488–2492
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Risser, R., Kaehler, D. (1985). Susceptibility to Abelson or Moloney Murine Leukemia Viruses. In: Potter, M. (eds) The BALB/c Mouse. Current Topics in Microbiology and Immunology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70740-7_24
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DOI: https://doi.org/10.1007/978-3-642-70740-7_24
Publisher Name: Springer, Berlin, Heidelberg
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