Genetic Control of the Macrophage Inflammatory Response Elicited in a Subcutaneous Site
Part of the
Current Topics in Microbiology and Immunology
book series (CT MICROBIOLOGY, volume 122)
Genetically determined differences exist between inbred mouse strains in the magnitude of the macrophage inflammatory response following elicitation with phlogistic agents such as thioglycollate (Stevenson, Kongshavn and Skamene 1981). This phenomenon was shown to be associated with a deficiency in the fifth component of complement (C5) in mouse strains which exhibited low macrophage inflammatory responses (Gervais, Stevenson and Skamene 1984). The present study was designed to further investigate the genetic control of the macrophage inflammatory response, using as the low responder strain the Balb/c mouse which is C5-sufficient while being a low macrophage inflammatory responder (unpublished observations). Genetic analysis was performed by typing for the trait of macrophage inflammatory responsiveness in recombinant inbred (RI) strains derived from Balb/cBy (low responder) and C57BL/6By (high responder) progenitor mouse strains.
KeywordsListeria Monocytogenes Recombinant Inbred Inbred Mouse Strain High Responder Genetic Linkage Analysis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Gervais F, Stevenson M and Skamene E (1984) Genetic control of resistance to Listeria monocytogenes: regulation of leukocyte inflammatory responses by the He locus. J Immunol 132:2078–2083.PubMedGoogle Scholar
Lusis AJ, Taylor BA, Wangenstein RW, LeBoeuf RC (1983) Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem 258:5071–5078.PubMedGoogle Scholar
Mathieson BJ, Sharrow SO, Bottomly K and Fowlkes BJ (1980) Ly 9, an alloantigenic marker of lymphocyte differentition. J Immunol 125:2127–2136.PubMedGoogle Scholar
Matsumoto T, Miake S, Mitsuyama M, Takeya K and Nomoto K (1982) Enhanced resistance to Listeria monocytogenes due to non-specifically activated macrophages in aged mice. J Clin Lab Immunol 8:51–54.PubMedGoogle Scholar
Stevenson MMS, Kongshavn PAL, Skamene E (1981) Genetic linkage of resistance to Listeria monocytogenes with macrophage inflammatory responses. J Immunol 127: 402–407.PubMedGoogle Scholar
© Springer-Verlag Berlin Heidelberg 1985