Susceptibility of BALB/c Sublines to Infection with Listeria Monocytogenes

  • E. Skamene
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


Inbred mice differ widely in their level of resistance to infection with Listeria monocytogenes. This observation was first made by Cheers and MacKenzie (1978) and independently confirmed in our laboratory (Skamene et al. 1979). Pertinent to the topics of this meeting, the strains which were found to be Listeria-susceptible included the BALB/c. The strain survey for resistance and susceptibility to Listeria described in the original paper of Cheers and MacKenzie classifed the following strains as resistant: C57BL/6J, C57BL/10ScSn, B10.D2/Sn, B10.A/SnSg, (B10.A × A) NZB/WEH1, B6C-H-2dBy, SJL/WEH1 and B6.PL (74NS)/Cy. Their susceptible strains (which succumbed to 1/100 equivalent of the lethal dose of resistant strains) were listed as follows: BALB/cJ, CBA/H, DBA/1J, WB/Re and 129/J. The BALB/cJ mice used in their experiments were derived from the Jackson Laboratory, Bar Harbor, and they were maintained in the laboratories in Melbourne by strict brother-sister mating. Segregation analysis of the trait of Listeria resistance/susceptibility, using the BALB/cJ as a susceptible progenitor and the C57BL/6J as a resistant progenitor led to the conclusion that a single, dominant gene in the C57BL/6J genome regulated the mechanism of resistance, with BALB/cJ carrying the allelic variant of this gene conferring the susceptibility of that strain. This gene, unmapped at that point was named Lr (for Listeria resistance).


Listeria Monocytogenes Recombinant Inbred Strain Open Coloni Strain Distribution Pattern Hemolytic Complement Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cheers C, MacGeorge J (1982) Genetics and cellular mechanisms of natural resistance to intracellular bacteria. In: Herberman RB (ed) NK cells and other natural effector cells. Academic Press, New York, p 1513Google Scholar
  2. Cheers C, McKenzie IFC, Mandel TE, Chan Y (1980) A single gene (Lr) controlling natural resistance to murine listeriosis. In: Skamene E, Kongshavn PAL, Landy M (eds) Genetic control of natural resistance to infection and malignancy, Academic Press, New York, p 141Google Scholar
  3. Cheers C, McKenzie IFC (1978) Resistance and susceptibility of mice to bacterial infection: I. Genetics of listeriosis. Infect Immun 19:755–762PubMedGoogle Scholar
  4. Cheers C, McKenzie IFC, Pavlov H, Waid C, York J (1978) Resistance and susceptibility of mice to bacterial infection: II. Course of listeriosis in resistant or susceptible mice. Infect Immun 19:765–770Google Scholar
  5. Gervais F, Stevenson M, Skamene E (1984) Genetic control of resistance to Listeria monocytogenes: Regulation of leukocyte inflammatory responses by the He locus. J Immunol 132:2078–2083PubMedGoogle Scholar
  6. Mandel TE, Cheers C (1980) Resistance and susceptibility of mice to bacterial infection. III. Histopathology of listeriosis in resistant and susceptible mice. Infect Immun 30:851–861PubMedGoogle Scholar
  7. Sadarangani C, Skamene E, Kongshavn PAL (1980) Cellular basis for enhanced resistance of certain mouse strains to listeriosis. Infect Immun 28:381–386PubMedGoogle Scholar
  8. Skamene E, Kongshavn PAL, Sachs DH (1979) Resistance to Listeria monocytogenes in mice is genetically controlled by genes which are not linked to the H-2 complex. J Infect Dis 139:228–231PubMedCrossRefGoogle Scholar
  9. Terry WD, Borsos T, Rapp HJ (1964) Differences in serum complement activity among inbred strains of mice. J Immunol 92:576PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • E. Skamene

There are no affiliations available

Personalised recommendations