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Genetic Control of Systemic Leishmania major Infection: Identification of Subline Differences for Susceptibility to Disease

  • B. A. Mock
  • A. H. Fortier
  • M. Potter
  • J. Blackwell
  • C. A. Nacy
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)

Abstract

There is universal agreement among protozoologists working with Leishmania that the BALB/c mouse is especially susceptible to infection with these reticuloendothelial cell pathogens. A random survey of mouse strain distributions for susceptibility to different Leishmania species suggests that the BALB/c may be unique in this regard: it is the only reported strain that is susceptible to both cutaneous and visceral leishmaniases (Bradley 1977; DeTolla, Scott & Farrell 1981; Howard, Hale & Chan-Liew 1980; Perez, Arredondo & Gonzalez 1978). The genetics of innate resistance to one of the visceral leishmanias, L. donovani, has been analyzed in detail (Bradley, Taylor, Blackwell, Evans & Freeman 1979): early control of intrahepatic replication of the parasite is regulated in intravenously (iv) inoculated mice by a gene on chromosome 1, Lsh. This gene, or a cluster of tightly linked genes, controls early resistance of mice to several distinctly different intracellular pathogens: Salmonella typhimurium (Plant & Glynn 1976; Taylor & O’Brien 1982;) Mycobacterium bovis (BCG) (Gros, Skamene & Forget 1981), M. lepraemurium (Skamene, Gros, Forget, Patel & Nesbitt 1984); and M. intracellulare (Goto, Nakamura, Takahashi & Tokunaga 1984); and L. donovani (Bradley et al. 1979).

Keywords

Visceral Leishmaniasis Inbred Mouse Cutaneous Leishmaniasis Congenic Strain Mycobacterium Bovis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. A. Mock
  • A. H. Fortier
  • M. Potter
  • J. Blackwell
  • C. A. Nacy

There are no affiliations available

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