Genetic Control of Systemic Leishmania major Infection: Identification of Subline Differences for Susceptibility to Disease

  • B. A. Mock
  • A. H. Fortier
  • M. Potter
  • J. Blackwell
  • C. A. Nacy
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


There is universal agreement among protozoologists working with Leishmania that the BALB/c mouse is especially susceptible to infection with these reticuloendothelial cell pathogens. A random survey of mouse strain distributions for susceptibility to different Leishmania species suggests that the BALB/c may be unique in this regard: it is the only reported strain that is susceptible to both cutaneous and visceral leishmaniases (Bradley 1977; DeTolla, Scott & Farrell 1981; Howard, Hale & Chan-Liew 1980; Perez, Arredondo & Gonzalez 1978). The genetics of innate resistance to one of the visceral leishmanias, L. donovani, has been analyzed in detail (Bradley, Taylor, Blackwell, Evans & Freeman 1979): early control of intrahepatic replication of the parasite is regulated in intravenously (iv) inoculated mice by a gene on chromosome 1, Lsh. This gene, or a cluster of tightly linked genes, controls early resistance of mice to several distinctly different intracellular pathogens: Salmonella typhimurium (Plant & Glynn 1976; Taylor & O’Brien 1982;) Mycobacterium bovis (BCG) (Gros, Skamene & Forget 1981), M. lepraemurium (Skamene, Gros, Forget, Patel & Nesbitt 1984); and M. intracellulare (Goto, Nakamura, Takahashi & Tokunaga 1984); and L. donovani (Bradley et al. 1979).


Visceral Leishmaniasis Inbred Mouse Cutaneous Leishmaniasis Congenic Strain Mycobacterium Bovis 
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  1. Bailey DW (1978) Sources of subline divergence and their relative importance for sublines of six major inbred strains of mice. In: Morse HC (ed) Origins of inbred mice. Academic Press, New York, p 197–215Google Scholar
  2. Bradley DJ (1977) Regulation of Leishmania populations within the host. II. Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin Exp Immunol 30:130–140PubMedGoogle Scholar
  3. Bradley DJ, Taylor BA, Blackwell JM, Evans EP, Freeman J (1979) Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin Exp Immunol 37:7–14PubMedGoogle Scholar
  4. Crocker PR, Blackwell JM, Bradley DJ (1984) Expression of the natural resistance gene Lsh in resident liver macrophages. Infect Immun 43:1033–1040PubMedGoogle Scholar
  5. DeTolla LJ, Scott PA, Farrell JP (1981) Single gene control of resistance to cutaneous leishmaniasis in mice. Immunogenetics 14:29–39PubMedCrossRefGoogle Scholar
  6. Fortier AH, Meitzer MS, Nacy CA (1984) Susceptibility of inbred mice to Leishmania tropica infection: genetic control of the development of cutaneous lesions in P/J mice. J Immunol 133:454–459PubMedGoogle Scholar
  7. Goto Y, Nakamura RM, Takahashi H, Tokunaga T (1984) Genetic control of resistance to Mycobacterium intracellular infection in mice. Infect Immun 46:135–140PubMedGoogle Scholar
  8. Gros P, Skamene E, Forget AJ (1981) Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol 127:2417–2421PubMedGoogle Scholar
  9. Howard JG, Hale C, Chan-Liew WL (1980) Immunological regulation of experimental cutaneous leishmaniasis. 1. Immunogenetic aspects of susceptibility to Leishmania tropica in mice. Parasite Immunol 2:303–314PubMedCrossRefGoogle Scholar
  10. Lissner CR, Swanson RN & O’Brien AD (1983) Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J Immunol 131:3006–3013PubMedGoogle Scholar
  11. Morse HC (1978) Differences among sublines of inbred mouse strains. In: Morse HC (ed) Origins of inbred mice. Academic Press, New York, p 441–444Google Scholar
  12. Nacy CA, Fortier AH, Pappas MG, Henry RR (1983) Susceptibility of inbred mice to Leishmania tropica infection: correlation of susceptibility with in vitro defective macrophage microbicidal activities. Cell Immunol 77:398–307CrossRefGoogle Scholar
  13. Perez H, Arredondo B, Gonzalez M (1978) Comparative study of American cutaneous leishmaniasis and diffuse cutaneous leishmaniasis in two strains of inbred mice. Infect Immun 22:302–307Google Scholar
  14. Plant JE, Glynn AA (1976) Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis 133:72–78PubMedCrossRefGoogle Scholar
  15. Plant JE, Blackwell JM, O’Brien AD, Bradley DJ, Glynn AA (1982) Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1? Nature 297:510–511PubMedCrossRefGoogle Scholar
  16. Potter M, O’Brien AD, Skamene E, Gros P, Forget A, Kongshavn PAL, Wax JS (1983) A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites. Infect Immun 40:1234–1235PubMedGoogle Scholar
  17. Scott PA, Farrell JP (1982) Experimental cutaneous leishmaniasis: disseminated leishmaniasis in genetically susceptible and resistant mice. Am J Trop Med & Hyg 31:230–238Google Scholar
  18. Skamene E, Gros P, Forget A, Patel PJ, Nesbitt MN (1984) Regulation of resistance to leprosy by chromosome 1 locus in the mouse. Immunogenetics 19:117–124PubMedCrossRefGoogle Scholar
  19. Taylor BA, O’Brien AD (1982) Position on mouse chromosome 1 of a gene that controls resistance to Salmonella typhimurium. Infect Immun 36:1257–1260PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. A. Mock
  • A. H. Fortier
  • M. Potter
  • J. Blackwell
  • C. A. Nacy

There are no affiliations available

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