DNA Hybridization Subtraction: Differences Detected Between BALB/cAnPt and BALB/cJax at the DNA Level

  • K. Huppi
  • A. von Deimling
  • J. Mushinski
  • M. Potter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)


A number of investigators have demonstrated DNA probes which map specifically to sex chromosomes X or Y (Kunkel et al. 1976; Schmeckpeper et al. 1979; Singh and Jones 1982; Lamar and Palmer 1984). The most recent report (Lamar and Palmer, 1984) has identified mouse chromosome Y specific sequences through the use of recombinant DNA techniques. Similar approaches have been made by D’Eustachio (1984) to obtain DNA fragments specific for mouse chromosome 12. We have adopted and modified a method of subtraction hybridization (Lamar and Palmer, 1984) to obtain recombinant DNA clones which distinguish closely related sublines of BALB/c inbred mice at autosomal loci.


Autosomal Locus Major Histocompatibility Complex Locus Plasma Cell Neoplasm Specific Genotypic Difference Lymphocyte Alloantigen 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • K. Huppi
  • A. von Deimling
  • J. Mushinski
  • M. Potter

There are no affiliations available

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