DNA Hybridization Subtraction: Differences Detected Between BALB/cAnPt and BALB/cJax at the DNA Level
A number of investigators have demonstrated DNA probes which map specifically to sex chromosomes X or Y (Kunkel et al. 1976; Schmeckpeper et al. 1979; Singh and Jones 1982; Lamar and Palmer 1984). The most recent report (Lamar and Palmer, 1984) has identified mouse chromosome Y specific sequences through the use of recombinant DNA techniques. Similar approaches have been made by D’Eustachio (1984) to obtain DNA fragments specific for mouse chromosome 12. We have adopted and modified a method of subtraction hybridization (Lamar and Palmer, 1984) to obtain recombinant DNA clones which distinguish closely related sublines of BALB/c inbred mice at autosomal loci.
KeywordsAutosomal Locus Major Histocompatibility Complex Locus Plasma Cell Neoplasm Specific Genotypic Difference Lymphocyte Alloantigen
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