Advertisement

Genetic Variation in Catecholamine Responsive Metabolic Pathways — A Hypothesis for a Common Regulatory Mechanism in BALB/c Sublines

  • L. P. Kozak
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 122)

Abstract

After completing an evaluation of the amino acid substitutions fixed in the albumin protein during the evolution of frogs and mammals, Allan Wilson and colleagues (1974) speculated that evolution at the level of the organism depends primarily on changes in regulatory genes rather than changes in structural genes, an idea that was postulated earlier by Britten and Davidson (1969). Over the past 10 years several genetic differences in enzyme levels which appear regulatory in nature have been observed among the sublines of the BALB/c strain of mouse. Generally, BALB/cJ varies from the other sublines, suggesting that during the 48 years since these sublines were separated, mutations occurred in genes which control the quantitative variations, or there was residual heterozygosity at the time of the separation, or both. At present there is only one reported potentially structural gene variation among the BALB/c sublines, a deletion which may cover part of the regulatory or coding region of the Qa-2 gene (Flaherty et al. 1985). Although this deletion can satisfactorily define mouse strains which are Qa-2 + or Qa-2 , it is unclear how the deletion to the Qa-2 gene could explain many of the other variations. It would appear, therefore, that investigation of the quantitative differences among the BALB/c sublines offers an opportunity to identify variant regulatory genes with pleiotropic effects.

Keywords

Brown Adipose Tissue Alpha Fetoprotein Variant Regulatory Gene Mitochondrial Uncouple Protein Murine Major Histocompatibility Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barnard T, Mory G, Nechad M (1980) Biogenic amines and the trophic response of brown adipose tissue. In: Parvez H and Parvez S (eds) Biogenic amines in development, Elsevier/North-Holland Biomedical Press, Amsterdam, p 391Google Scholar
  2. Belayew A, Tilghman SM (1982) Genetic analysis of a-fetoprotein synthesis in mice. Mol Cell Biol 2:1427–1435PubMedGoogle Scholar
  3. Bouillaud F, Ricquier D, Mory G, Thibault J (1984) Increased level of mRNA for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or norepinephrine infusion. J Biol Chem 259:11583–11586PubMedGoogle Scholar
  4. Britten RJ, Davidson EH (1969) Gene regulation for higher cells: a theory. Science 165:349–357PubMedCrossRefGoogle Scholar
  5. Ciaranello R, Axelrod J (1973) Genetically controlled alterations in the rate of degradation of phenylethanolamine N-methyltransferase. J Biol Chem 248:5616–5623PubMedGoogle Scholar
  6. Ciaranello RD, Hoffman HJ, Shire JGM, Axelrod J (1974) Genetic regulation of the catecholamine biosynthetic enzymes. J Biol Chem 249:4528–4536PubMedGoogle Scholar
  7. Ciaranello RD, Lipsky A, Axelrod J (1974) Association between fighting behavior and catecholamine biosynthetic activity in two inbred mouse sublines. Proc Natl Acad Sci USA 71:3006–3008PubMedCrossRefGoogle Scholar
  8. Coleman DL (1980) Genetic control of serine dehydratase and phosphoenolpyruvate carboxykinase in mice. Biochem Genet 18:969–979PubMedCrossRefGoogle Scholar
  9. Cook JR, Stadler U, Burkart D, Kozak LP (1985) Genetic regulation of sn-glycerol- 3-phosphate dehydrogenase in brown adipose tissue, (submitted)Google Scholar
  10. Falconer DS (1960) Introduction to quantitative genetics, Ronald, New YorkGoogle Scholar
  11. Flaherty L, DiBiase K, Lynes MA, Seidman JG, Weinberger O, Rinchik EM (1985) Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci USA 82:1503–1507PubMedCrossRefGoogle Scholar
  12. Jacobsson A, Stadler U, Glotzer MA, Kozak LP (1985) Mitochondrial uncoupling protein from mouse brown fat: molecular cloning, genetic mapping and expression of a cDNA sequence, (submitted)Google Scholar
  13. Kozak LP (1985) Interacting genes control glycerol-3-phosphate dehydrogenase expression in developing cerebellum of the mouse. Genetics 110:123–143PubMedGoogle Scholar
  14. Nedergaard J, Lindberg O(1982) The brown fat cell. Intern Rev Cytol 74:187–286CrossRefGoogle Scholar
  15. Nicholls GD, Locke RM (1984) Thermogenic mechanisms in brown fat. Physiol Rev 64:1–64PubMedGoogle Scholar
  16. Olsson M, Lindahl G, Ruoslahti E (1977) Genetic control of alpha fetoprotein synthesis in the mouse. J Exp Med 145:819–827PubMedCrossRefGoogle Scholar
  17. Ratner PL, Fisher M, Burkart D, Cook JR, Kozak LP (1981) The role of mRNA levels and cellular localization in controlling sn-glycerol-3-phosphate dehydrogenase expression in tissues of the mouse. J Biol Chem 256:3576–3579PubMedGoogle Scholar
  18. Ricquier D, Kader JC (1976) Mitochondrial protein alteration in active brown fat: A sodim dodecyl sulfate-polyacrylamide gel electrophoretic study. Biochem Biophys Res Commun 73:577–583PubMedCrossRefGoogle Scholar
  19. Tolbert MEM, Fain NJ (1974) Studies in the regulation of gluconeogenesis in isolated rat liver cells by epinephrine and glucagon. J Biol Chem 249:1162–1166Google Scholar
  20. Wilson AC, Maxson LR, Sarich VM (1974) Two types of molecular evolution. Evidence from studies of interspecific hybridization. Proc Natl Acad Sci USA 71:2843–2847PubMedCrossRefGoogle Scholar
  21. Yoo-Warren H, Cimbala MA, Felz K, Monahan JE, Leis JP, Hanson RW (1981) Identification of a cDNA clone to phosphoenlpyruvate carboxykinase (GTP) from rat cytosol. J Biol Chem 256:10224–10227PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • L. P. Kozak

There are no affiliations available

Personalised recommendations