Focal Flow Disturbances in Acute Strokes: Effects on Regional Metabolism and Tissue pH

  • Y. L. Yamamoto
  • A. M. Hakim
  • M. Diksic
  • R. P. Pokrupa
  • E. Meyer
  • J. Tyler
  • A. C. Evans
  • K. Worsley
  • C. J. Thompson
  • W. H. Feindel

Abstract

In acute stroke, the reduction of blood flow causes tissue damage and sets of a complex escalating chain reaction from acid metabolites and also from products of disturbed intracellular ionic homeostasis. These events may lead to lipolysis and proteolysis [35, 41]. Although regional cerebral blood flow (rCBF) is an appropriate function to measure in acute stroke, recent studies have revealed that it varies widely inpatients with similar neurologic deficits from stroke. Moreover, 133Xe intracarotid studies have shown focal hyperemia to be a striking early feature in some patients with stroke [29,42–44] and for this reason also, rCBF is a poor indicator of residual cerebral tissue function. In contrast, positron emission tomography (PET) imaging has shown a consistently reduced regional cerebral metabolic rate (below 67 µmol/100g/min) for oxygen (rCMRO2) in the infarcted area [30, 48, 49].

Keywords

Ischemia Neurol Bismuth Fluorescein Hyperglycemia 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Y. L. Yamamoto
  • A. M. Hakim
  • M. Diksic
  • R. P. Pokrupa
  • E. Meyer
  • J. Tyler
  • A. C. Evans
  • K. Worsley
  • C. J. Thompson
  • W. H. Feindel

There are no affiliations available

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