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Uncoupling of Flow and Metabolism in Infarcted Tissue

  • Conference paper
Book cover Functional Mapping of the Brain in Vascular Disorders

Abstract

In order to study the relationship between regional cerebral blood flow and metabolism, it is necessary to measure these entities of tissue function independently. The use of gamma-ray-emitting radioisotopes to trace physiological/biochemical pathways, and radiation detectors placed external to the body, enables regional tissue function to be measured without disturbing the subject’s physiological state. The paper presented by Dr. Ter-Pogossian in this symposium describes how shortlived positron-emitting radioisotopes of oxygen, nitrogen, carbon, and fluorine can be used as labels for in vivo tracer studies. He also demonstrates that by positron emission tomographic (PET) scanning, the transaxial tomographic distribution of these isotopes can be recorded throughout the body. Furthermore, by applying a correction for attenuation effects, it is possible to measure absolute levels of regional tissue concentrations of tracer. This is an important aspect of PET scanning, since it enables concentrations of tracer in blood, measured from samples, to be expressed in the same units as the tracer concentration in the tissues. Thus, appropriate tracer models formulated to define the fate of the labelled molecules can be solved to derive absolute values of the physiological entity being traced.

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Authors
  1. T. Jones
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  2. R. J. S. Wise
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  3. R. S. J. Frackowiak
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  4. J. M. Gibbs
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  5. G. L. Lenzi
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  6. S. Herold
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Editors and Affiliations

  1. Max-Planck-Institut für neurologische Forschung Abteilung für allgemeine Neurologie und Neurologische Klinik, Krankenhaus Merheim, Ostmerheimer Straße 200, 5000, Köln 91, Germany

    Wolf-Dieter Heiss

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Jones, T., Wise, R.J.S., Frackowiak, R.S.J., Gibbs, J.M., Lenzi, G.L., Herold, S. (1985). Uncoupling of Flow and Metabolism in Infarcted Tissue. In: Heiss, WD. (eds) Functional Mapping of the Brain in Vascular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70720-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-70720-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15801-1

  • Online ISBN: 978-3-642-70720-9

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