Bone Turnover Assessment Using Bone-Specific Biochemical Markers

  • K. G. Mann
  • B. L. Riggs
Conference paper


Simple, noninvasive methods for determining bone formation and bone resorption are urgently needed which are well-characterized, specific, and accurate. The lack of such methods severely contrains research of the pathophysiology of osteoporosis, other bone-losing metabolic disorders, and of the clinical evaluation of treatment. Radiocalcium kinetic studies combined with external calcium balance include a variable, nonresolvable long-term exchange component (which may represent as much as one-half of the computed bone turnover rate)(Riggs et al, 1971). Moreover, these methods, requiring the administration of radioactivity, are time-consuming and expensive. Bone histomorphometry, the other commonly employed technique measuring local rather than overall bone turnover, cannot guantify bone resorption rate accurately and requires an invasive procedure (Frost, 1973).


Bone Resorption Bone Turnover Bone Matrix Postmenopausal Osteoporosis Serum Alkaline Phosphatase 
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© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. G. Mann
  • B. L. Riggs

There are no affiliations available

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