Bone Turnover Assessment Using Bone-Specific Biochemical Markers
Simple, noninvasive methods for determining bone formation and bone resorption are urgently needed which are well-characterized, specific, and accurate. The lack of such methods severely contrains research of the pathophysiology of osteoporosis, other bone-losing metabolic disorders, and of the clinical evaluation of treatment. Radiocalcium kinetic studies combined with external calcium balance include a variable, nonresolvable long-term exchange component (which may represent as much as one-half of the computed bone turnover rate)(Riggs et al, 1971). Moreover, these methods, requiring the administration of radioactivity, are time-consuming and expensive. Bone histomorphometry, the other commonly employed technique measuring local rather than overall bone turnover, cannot guantify bone resorption rate accurately and requires an invasive procedure (Frost, 1973).
KeywordsBone Resorption Bone Turnover Bone Matrix Postmenopausal Osteoporosis Serum Alkaline Phosphatase
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- 2.Brown, J.P., Delmas, P.D., Malaval, L., Edouard, C., Chapuy, M.C., and Meunier, P.J.: Serum bone Glaprotein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 10 91, 1984.Google Scholar
- 7.Duda, R.J., Jr., Mann, K.G., and Riggs, B.L.: Calcitriol stimulation test for osteoblast function: Results in postmenopausal osteoporosis. Proc. 7th Annual Scientific Meeting, American Society for Bone and Mineral Research, June 15–18, 1985. Abstract #129.Google Scholar
- 9.Farley, J.R., Chesnut, C.H., III, and Baylink, D.J.: Improved method for quantitative determination in serum of alkaline phosphatase of skeletal origin. Clin. Chem. 27, 2002, 1981.Google Scholar
- 10.Frost, H.M.: Bone remodeling and its relationship to metabolic bone diseases. In, Orthopedic Lecture Series, Charles C. Thomas, Springfield, 111, Vol. 8, 1973.Google Scholar
- 16.Lian, J.B., Tassinari, M., and Glowacki, J.: Resorption of implanted bone prepared from normal and warfarin-treated rats. J. Clin. Invest. 73, 12 1984.Google Scholar
- 17.Meunier, P.J., Sellami, S., Briangon, D., and Edouard, C.: Histological heterogeneity of apparently idiopathic osteoporosis. In, Osteoporosis: Recent Advances in Pathogenesis and Treatment. Eds: DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C., Jr., Parfitt, A.M. University Park Press, Baltimore, 1980, p. 293.Google Scholar
- 19.Parfitt, A.M., Mathews, C., Rao, D., Frame, B., Kleerekoper, M., and Villaneuva, A.R.: Impaired osteoblast function in metabolic bone disease. In, Osteoporosis: Recent Advances in Pathogenesis and Treatment. Eds: DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C., Jr., Parfitt, A.M. University Park Press, Baltimore, 1980, p. 321.Google Scholar
- 21.Price, P.: Osteocalcin. In, Bone and Mineral Research, Annual I. Ed: Peck, W.A., Excerpta Medica, Amsterdam, Oxford, Princeton, 1983, pp 157–190.Google Scholar
- 22.Price, P.A., and Baukol, S.A.: 1,25-dihydroxyvitamin D3 increases synthesis of the vitamin D-dependent bone protein by osteosarcoma cells. J. Biol. Chem. 255, 1 1660, 1980.Google Scholar
- 26.Riggs, B.L., Tsai, K.-S., and Mann, K.G.: Evidence that serum bone Gla-protein is a measure of bone formation but not of bone resorption. Proc. 6th Annual Scientific Meeting, American Society for Bone and Mineral Research, June 26–29, 1984.Google Scholar