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Paget’s Disease of Bone (Osteitis deformans)

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Current Concepts of Bone Fragility

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Abstract

Sir James Paget presented five cases illustrating a chronic, slowly progressive and disabling bone disorder to the Medical and Chirurgical Society of London on November 14, 1876 (Handy, 1981). A century later, we are able to apply medical therapy which slows the progress of the disease in many patients but cures none. The etiology of Paget’s disease remains obscure, although recent evidence suggests (but does not prove), that its cause is a putative viral infection of skeletal osteoclasts.

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References

  1. Alexandre: Personal Communication

    Google Scholar 

  2. Barker, D.J., Chamberlain, A.T., Guyer, P.B., Gardner, M.J.: Paget’s disease of bone in 14 British towns. Brit.Med.J. 1, 1181, 1981.

    Article  Google Scholar 

  3. Bijvoet, O.L.M.: Bisphosphonate treatment for Paget’s disease of bone. In, Clinical Disorders of Bone and Mineral Metabolism. Eds: Frame, B. and Potts, J.T. Excerpta Medica, Amsterdam, 1984. pp 389–393.

    Google Scholar 

  4. Bijvoet, O.L.M., Frijlink, W.B., et al: APD in Paget’s disease of bone. Arthritis Rheum. 23, 1193, 1980.

    Article  PubMed  CAS  Google Scholar 

  5. de Deuxchaisnes, C.N.: Do calcitonins help Paget’s disease. In, Clinical Disorders of Bone and Mineral Metabolism. Eds: Frame,B. and Potts, J.T. Excerpta Medica, Amsterdam, 1984. pp 384–388.

    Google Scholar 

  6. de Deuxchaisnes, et al: Therapeutic regimens in Paget’s disease of bone. Arthritis Rheum. 23_, 1225, 1980.

    Google Scholar 

  7. Frijlink, W.B., TeVelde, J., Bijvoet, O.L., and Heynen, G.: Treatment of Paget’s disease with (3-amino-l-hydroxypropylidene)-1, bisphosphonate (APD). Lancet 1, 799, 1979.

    Article  PubMed  CAS  Google Scholar 

  8. Gherardi, G., Lo Cascio, V., and Bonucci, E.: Fine structure of nuclei and cytoplasm of osteoclasts in Paget’s disease of bone. Histopathology 4, 63, 1981.

    Article  Google Scholar 

  9. Gundberg, C.M., Lian, J.B., Gallop, P.M., and Steinberg, J.J.: Urinary gamma carboxyglutamic acid and serum osteocalcin as bone markers: Studies in osteoporosis and Paget’s disease. J.Clin.Endo.Metab. 57, 1221, 1983.

    Article  CAS  Google Scholar 

  10. Handy, R.C.: Paget’s Disease of Bone. Assessment and Management. Praeger Publ., Great Britain, 1981.

    Google Scholar 

  11. Howatson, A.F. and Fornasier, V.L.: Microfilaments associated with Paget’s disease of bone: Comparison with nucleocapsids of measles virus and respiratory syncytial virus. Intervirology 18, 151, 1982.

    Article  Google Scholar 

  12. Johnston, C.C., Altman, R.D., Canfield, R.E., Finerman, G.A.M., Taulbee, J.D., and Ebert, M.L.: Review of fracture experience during treatment of Paget’s disease of bone with etidronate disodium (EHDP). Clin. Orthop. 172, 186, 1983.

    PubMed  Google Scholar 

  13. Krane, S.M., Kantrowitz, F.G., Byrne, M., Pinnell, S.R., and Singer, F.R.: Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. J.Clin.Invest. 59, 819, 1977

    Article  PubMed  CAS  Google Scholar 

  14. MacIntyre, I., Evans, I.M., Hobitz, M.H.G., Joplin, G.F., and Stevenson, J.C.: Chemistry, physiology and therapeutic applications of calcitonin. Arthritis Rheum. 23, 1139, 1980

    Article  PubMed  CAS  Google Scholar 

  15. Mautalen, C.A.: Treatment of Paget’s bone disease with bisphosphonate APD. Henry Ford Hosp.Med.J. 31, 244, 1983.

    PubMed  CAS  Google Scholar 

  16. Merkow, R.L. and Lane, J.M.: Current concepts of Paget’s disease of bone. Ortho.Clin.N.A. 15, 747, 1984

    CAS  Google Scholar 

  17. Mills, B. and Singer, F.: Nuclear inclusions in Paget’s disease of bone. Science 194, 211, 1976.

    Article  Google Scholar 

  18. Mills, B.G., Singer, F.R., Weiner, L.P., and Hoist, P.A.: Immunohistological demonstration of respiratory syncytial virus antigens in Paget’s disease of bone. Proc.Nat.Acad.Sci. 78, 1219, 1981.

    Article  Google Scholar 

  19. Mills, B.G., Singer, F.R., Weiner, L.P., Suffin, S.C., Stabile, E., and Hoist, P.: Evidence for both respiratory syncytial virus and measles virus antigens in the osteoclasts of patients with Paget’s disease of bone. Clin. Orthop. 183, 313, 1984.

    Google Scholar 

  20. Mulivor, R.A., Boccelli, D., and Harris, H.: Quantitative analysis of alkaline phosphatases in serum and amniotic fluid: Comparison of biochemical and immunologic assays. J. Lab. Clin. Med. 115, 342, 1985.

    Google Scholar 

  21. Niell, H.B., Palmieri, G.M., Neely, C.L., and McDonald, M.W.: Postabsorptive urinary hydroxyproline test in patients with metastatic bone disease from breast cancer. Arch. Int. Med. 141, 1471, 1981.

    Article  CAS  Google Scholar 

  22. Perry, H.M., Droke, D.M., and Avioli, L.V.: Alternate calcitonin and etidronate disodium therapy for Paget’s bone disease. Arch. Int. Med. 144, 929, 1984.

    Article  Google Scholar 

  23. Revel, A., Bregeon, C., Basle, M., and Malkani, K.: Is Paget’s bone disease a viral infection? Calcif. Tiss. Res. 22, 283, 1975.

    Google Scholar 

  24. Ryan, W.G.: Pathophysiology and modern management of Paget’s disease. Compreh. Therapy 9, 64, 1983.

    CAS  Google Scholar 

  25. Ryan, W.G. and Schwartz, T.B.: Mithramycin treatment of Paget’s disease of bone. Arthr. Rheum. 23, 1155, 1980.

    Article  CAS  Google Scholar 

  26. Simon, L.S., Krane, S.M., Wortman, P.D., Krane, I.M., and Kovitz, K.L.: Serum levels of type I and III procollagen fragments in Paget’s disease of bone. J. Clin. Endo. Metab. 58, 110, 1984.

    Article  CAS  Google Scholar 

  27. Singer, F.R. and Ahrne-Collier, I: Salmon calcitonin therapy: antibodies and clinical resistance in patients with Paget’s disease of bone In, Proc. Conference on Molecular Endocrinology, Endocrinology’77. Eds: Maclntyre, I. and Szelke, M., Elsevier./North Biomedical Press, Amsterdam, New York, 1977, pp 207–213.

    Google Scholar 

  28. Singer, F.R., Mills, B.G., Park, M.S., Takemura, S., and Teraskai, P.I. Increased HLA-DQW. Antigen pattern in Paget’s disease of bone. Clin. Res. 33, 547A, 1985.

    Google Scholar 

  29. Singer, F.R., Schiller, A., Pyle, E.B., and Krane, S.M.: Paget’s disease of bone. In, Metabolic Bone Disease, Vol. 2. Eds: Avioli, L. and Krane, S., Academic Press, New York, 1978, p. 492.

    Google Scholar 

  30. Siris, E.S., Jacobs, T.P., and Canfield, R.E.: Paget’s disease of bone. Bull. N.Y. Acad. Med. 56, 285, 1981.

    Google Scholar 

  31. Smith, M.L., Fogelman, I., Ralston, S., Boyce, B.F., and Boyle, I.T.: Correlation of skeletal uptake of 99m-Tc-diphosphonate and alkaline phosphatase before and after oral disphosphonate therapy in Paget’s disease. Metab. Bone Dis. Rel. Res. 5, 167, 1984.

    Article  CAS  Google Scholar 

  32. Taubman, M.B., Kammerman, S., and Goldberg, B.: Radioimmunoassay of procollagen in serum of patients with Paget’s disease of bone. Proc. Soc. Exp. Biol. Med. 152, 284, 1976.

    PubMed  CAS  Google Scholar 

  33. Van Lente, R.: Alkaline and acid phosphatase determinations in bone disease. Orthop. Clin. N.A. 11, 437, 1979.

    Google Scholar 

  34. Vellenga, C., Pauwels, E.K., Bijvoet, O.L., Frijlink, W.B., Mulder, J.D., and Hermans, J.: Untreated Paget’s disease of bone studied by scintigraphy. Radiology 153, 799, 1984.

    PubMed  CAS  Google Scholar 

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Authors
  1. J. R. Shapiro
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Editors and Affiliations

  1. Division of Orthopaedic Surgery, University of Ottawa Ottawa General Hospital, 501 Smyth Road, K1H 8L6, Ottawa, Ontario, Canada

    Hans K. Uhthoff M.D.,FRCS (C) (Chairman and Professor) (Chairman and Professor)

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© 1986 Springer-Verlag Berlin Heidelberg

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Shapiro, J.R. (1986). Paget’s Disease of Bone (Osteitis deformans). In: Uhthoff, H.K. (eds) Current Concepts of Bone Fragility. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70709-4_21

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  • DOI: https://doi.org/10.1007/978-3-642-70709-4_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70711-7

  • Online ISBN: 978-3-642-70709-4

  • eBook Packages: Springer Book Archive

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