Biomechanical Factors in Adaptation of Bone Structure to Function

  • L. E. Lanyon
Conference paper

Abstract

The general form of each bone, its attachments, and its anatomical relationships are all genetically determined and will develop in the absence of functional influences. However, the particular features on which each bone’s load-bearing competence depends (ie, its mass, girth, cortical thickness, curvature, and the density and arrangement of its cancellous bone) are all achieved, and will only persist in the presence of continued functional load bearing. Normality of skeletal structure, and the load-bearing competence it reflects, is therefore not a predetermined state but rather the cumulative achievement of local adaptation to load bearing throughout the skeleton. Skeletal fragility may be viewed as a failure or insufficiency in the process which normally matches skeletal structure to its load-bearing requirements.

Keywords

Arthritis Estrogen Osteoporosis Turkey Posit 

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References

  1. 1.
    Burkhart, J.M., Jowsey, J.: Parathyroid and thyroid hormone in the development of immobilisation osteoporosis. Endocrinology 81, 1053, 1967.PubMedCrossRefGoogle Scholar
  2. 2.
    Carter, D.R., and Caler, W.E.: A cumulative damage model of bone fracture, J.Orthop. Res.3, 84, 1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Chantraine, A., Heynen, G., and Franchimont, P.: Bone metabolism, parathyroid hormone, and calcitonin in paraplegia. Calcif. Tissue Int.27, 199, 1979.PubMedCrossRefGoogle Scholar
  4. 4.
    Churches, A.E.,and Howlett, C.R.: The response of mature cortical bone to controlled time-varying loading. In, Mechanical Properties of Bone. Ed: Cowin, S.C., ASME publication AMD 45, 69, 1981.Google Scholar
  5. 5.
    Dalen, N., and Olsson, K.E.: Bone density in athletes. Clin.Orthop. Rel.Res.77, 179 1974.Google Scholar
  6. 6.
    Donaldson, C.L., Hulley, S.B., Vogel, J.M., Hattner, R.S., Bayers, J.H., and McMillan, D.E.: Effect of prolonged bedrest on bone mineral. Metabolism 19, 1071, 1970.PubMedCrossRefGoogle Scholar
  7. 7.
    Drivdahl, R.H., Howard, G.A., and Baylink, D.J.: Extracts of bone contain a potent regulator of bone formation. Biochem.Biophys.Acta 714, 23, 1982.Google Scholar
  8. 8.
    Frost, H.M.: Bone Modelling and Skeletal Modelling Errors. Charles C. Thomas, Illinois, 1973.Google Scholar
  9. 9.
    Goodship, A.E., Lanyon, L.E., and MacFie, H.: Functional adaptation of bone to increased stress. J. Bone Joint Surg.61A, 539, 1979.PubMedGoogle Scholar
  10. 10.
    Hert, J., Liskova, M., and Landa, J.: Reaction of bone to mechanical stimuli. Part 1: Continuous and intermittent loading of tibia in rabbit. Folia Morph. (Praha)19, 290, 1971.Google Scholar
  11. 11.
    Jones, H.H., Priest, J.D., Hayes, W.C., Tichenor, C.C., and Nagel, D.A.: Humeral hypertrophy in response to exercise. J.Bone Joint Surg.59A, 204, 1977.PubMedGoogle Scholar
  12. 12.
    Krolner, B. and Toft, B.: Vertebral bone loss: an unheeded side effect of therapeutic bed rest. Clin.Sc.64, 537, 1983.Google Scholar
  13. 13.
    Krolner, B., Toft, B., Nielsen, S.P., and Tondevold, E.: Physical exercise as prophylaxis against involutional bone loss: a controlled trial. Clin.Sc.64, 541, 1983.Google Scholar
  14. 14.
    Lanyon, L.E.: The measurement of bone strain in vivo. Acta Orthopaed. Belg. 42 (Suppl. l), 98, 1976.Google Scholar
  15. 15.
    Lanyon, L.E.: Functional strain as a determinant for bone remodelling. Calcif.Tis.Int.36, S56, 1984.CrossRefGoogle Scholar
  16. 16.
    Lanyon, L.E., Goodship, A.E., Pye, C.J., and MacFie, H.: Mechanically adaptive bone remodelling. A quantitative study on functional adaptation in the radius following ulna osteotomy in sheep. J. Biomech.15, 141, 1982.PubMedCrossRefGoogle Scholar
  17. 17.
    Lanyon, L.E., and Rubin C.T.: Static versus dynamic loads as an influence on bone remodelling. J. Biomech. 17, 897, 1984.PubMedCrossRefGoogle Scholar
  18. 18.
    O’Connor, J.A., Lanyon, L.E., and MacFie, H.: The influence of strain rate on adaptive bone remodelling. J.Biomech. 15, 767, 1982PubMedCrossRefGoogle Scholar
  19. 19.
    Rubin, C.T., and Lanyon, L.E.: Regulation of bone mass by peak strain magnitude. Trans. Orthopaed.Res.Soc., 1983.Google Scholar
  20. 20.
    Rubin, C.Tvand Lanyon, L.E.: Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. 66A, 397, 1984.Google Scholar
  21. 21.
    Rubin, C.TV and Lanyon, L.E.: Dynamic strain similarity in vertebrates: An alternative to allometric limbo bone scaling. J. Theor.Biol. 107, 321, 1984.PubMedCrossRefGoogle Scholar
  22. 22.
    Smith, E.L., Reddan, W., and Smith, P.E.: Physical activity and calcium modalities for bone mineral increase in aged women. Med.Sc.Sports Exerc. 13, 60, 1981.Google Scholar
  23. 23.
    Uhthoff, H.K. and Jaworski, Z.F.G.: Bone loss in response to long-term immobilisation. J. Bone Joint.Surg. 60B, 420, 1978.Google Scholar
  24. 24.
    Woo, S.L-Y., Kuei, S.C., Amiel, D., Gomez, M.A., Hayes, W.C., White, F.C., and Akeson, W.H.:.The effect of prolonged physical training on the properties of long bone: A study of Wolff’s Law. J. Bone Joint. Surg. 63A, 780, 1981.PubMedGoogle Scholar
  25. 25.
    Wronski, T.J., and Morey, E.R.: Inhibition of cortical and trabecular bone formation in the long bones of immobilised monkeys. Clin. Orthopaed. 181, 269, 1983.Google Scholar
  26. 26.
    Young, D.R., Niklowitz, W.J., and Steel, C.R.: Tibial changes in experimental disuse osteoporosis in the monkey. Calcif.Tis.Int. 35, 304, 1983CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1986

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  • L. E. Lanyon

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