Setpoint Proposal for Osteogenesis Imperfecta
This article summarizes the details of a possible pathogenetic mechanism in osteogenesis imperfecta (OGIM). It concerns the minimum effective strain (MES) described in a companion article in this volume (Frost, 1985a), specifically the strains involved in the control, by the mechanical usage of the skeleton, of its bone modeling, remodeling, and microdamage repair. The MES phenomenon was described by the author, based on clinical evidence, in 1963 (Frost, 1963). It has been supported by in vivo strain gauge studies of bone carried out in laboratory animals by a number of investigators since 1975 (Frost, in press).
KeywordsOsteogenesis Imperfecta Marrow Cavity Mechanical Usage Collagen Chemistry Increase Bone Fragility
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