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Setpoint Proposal for Osteogenesis Imperfecta

  • H. M. Frost

Abstract

This article summarizes the details of a possible pathogenetic mechanism in osteogenesis imperfecta (OGIM). It concerns the minimum effective strain (MES) described in a companion article in this volume (Frost, 1985a), specifically the strains involved in the control, by the mechanical usage of the skeleton, of its bone modeling, remodeling, and microdamage repair. The MES phenomenon was described by the author, based on clinical evidence, in 1963 (Frost, 1963). It has been supported by in vivo strain gauge studies of bone carried out in laboratory animals by a number of investigators since 1975 (Frost, in press).

Keywords

Osteogenesis Imperfecta Marrow Cavity Mechanical Usage Collagen Chemistry Increase Bone Fragility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Brown, D.M.: Biochemical abnormalities in osteogenesis imperfecta. Clin. Orthop. Rel. Res. 159, 75, 1981.Google Scholar
  2. 2.
    Frost, H.M.: An Introduction to Biomechanics, Charles C. Thomas, Springfield, 1963.Google Scholar
  3. 3.
    Frost, H.M.: Pathogenic mechanisms of the osteoporosis. In, Current Concepts of Bone Fragility in Orthopaedics and Medicine. Eds: H.-K. Uhthoff and E. Stahl, Springer-Verlag, 1985a.Google Scholar
  4. 4.
    Frost, H.M.: Osteogenesis imperfecta: The setpoint proposal. Clin. Orthop. Rel. Res. In pressGoogle Scholar
  5. 5.
    Frost, H.M.: Bone microdamage: Factors that impair its repair. In, Current Concepts of Bone Fragility in Orthopaedics and Medicine. Eds: H.-K. Uhthoff and E. Stahl, Springer-Verlag, 1985b.Google Scholar
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    Sillence, D.: Osteogenesis imperfecta. An expanding panorama of variants. Clin. Orthop. Rel. Res. 159, 11, 1981.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. M. Frost

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