Fetoplacental Products as a Prognostic Guide Following Chorionic Villi Sampling
The safety of chorionic villi sampling (CVS) as a clinical procedure in fetal diagnosis has yet to be fully assessed. Complications occurring immediately and several weeks after this procedure have been described, but it is still unclear to what extent the complication rate is related to the surgical aspect of the sampling. As some biochemical tests of placental function have been reported as helpful in the prediction of pregnancy outcome following vaginal bleeding, (Westergaard et al. 1983,1985), we have examined proteins of fetal (α-fetoprotein, AFP) and placental (human chorionic gonadotropin, HCG; pregnancy-specific Bi glycoprotein, SPI; and pregnancy-associated protein-A, PAPP-A) origin before and within 6 h of CVS.
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