Responses to Clonidine in Acute and Remitted Depressed Patients
A variety of studies reporting abnormal hormone responses to noradrenergic challenges point toward the possibility that a blunted growth hormone response to clonidine, reflecting decreased a2-adrenergic responsiveness, may constitute a trait or vulnerability marker for depression. These results contrast with preliminary data suggesting greater state dependence of indices of noradrenergic output, such as concentrations of the noradrenergic metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG) and hormones such as cortisol in biologic fluids.
KeywordsDepression Cortisol Prolactin Amphetamine Monoamine
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