Abstract
The effect of dexamethasone on brain infarcts has been the subject of numerous clinical and experimental studies [3, 4, 7, 8]. In most experimental investigations no beneficial effect of dexamethasone has been found. However, clinical studies and practice have suggested such an effect [1, 11]. The known experimental studies deal with the early phase of infarct when the vasogenic perifocal edema has not yet developed. On the other hand, a beneficial effect of dexamethasone in stroke patients has been observed many hours and even days after the stroke. Therefore, in the present investigation the effect of dexamethasone treatment on experimental brain infarcts has been studied over a long period.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson DC, Cranford RE (1979) Corticosteroids in ischemic stroke. Stroke 10:68–71
Barbosa-Coutinho LM, Hartmann A, Hossmann K-A, Rommel T (1984) Effect of dexamethasone on serum protein extravasation in experimental brain infarcts of monkey: an immunohistochemical study. Acta Neuropathol (in press)
Bremer AM, Yamada K, West CR (1980) Ischemic cerebral edema in primates: Effects of acetazolamide, phenytoin, sorbitol, dexamethasone, and methylprednisolone on brain water and electrolytes. Neurosurgery 6:149–154
Fenske A, Fischer M, Regli F, Hase U (1979) The response of focal ischemic cerebral edema to dexamethasone. J Neurol 220:199–209
Hartmann A, Menzel J, Buttinger C, Lange D, Alberti E (1981) Regional cerebral blood flow in the baboon during ischemic cerebral infarction under dexamethasone treatment. Fortschr Neurol Psychiatr 49:380–392
Hossmann K-A, Hürter T, Oschlies U (1983) The effect of dexamethasone on serum protein extravasation and edema development in experimental brain tumors of cat. Acta Neuro-pathol(Berl) 60:223–231
Kahn K, Pranzarone G, Newman T (1972) Dexamethasone treatment of experimental cerebral infarction. Neurology 22:406–407
Lee MC, Mastri AR, Waltz AG, Loewenson RB (1974) Ineffectiveness of dexamethasone treatment of experimental cerebral infarction. Stroke 5:216–225
Pappius HM (1982) Dexamethasone and local cerebral glucose utilization in freeze-trau-matized rat brain. Ann Neurol 12:157–162
Pappius HM, Wolfe LS (1983) Functional disturbances in brain following injury: search for underlying mechanisms. Neurochem Res 8:63–72
Sage JI, van Uitert RL (1982) Clinical benefit of steroids in early postischemic disruption of the blood-brain barrier. Ann Neurol 12:84–85
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hartmann, A., Hossmann, KA., Czernicki, Z., Barbosa-Coutinho, L.M., Ebhardt, G., Menzel, J. (1985). Effect of Dexamethasone on Regional Cerebral Blood Flow and on Serum Protein Extravasation in Experimental Brain Infarcts in Monkeys. In: Inaba, Y., Klatzo, I., Spatz, M. (eds) Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70696-7_97
Download citation
DOI: https://doi.org/10.1007/978-3-642-70696-7_97
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70698-1
Online ISBN: 978-3-642-70696-7
eBook Packages: Springer Book Archive