Effect of Dexamethasone on Regional Cerebral Blood Flow and on Serum Protein Extravasation in Experimental Brain Infarcts in Monkeys
The effect of dexamethasone on brain infarcts has been the subject of numerous clinical and experimental studies [3, 4, 7, 8]. In most experimental investigations no beneficial effect of dexamethasone has been found. However, clinical studies and practice have suggested such an effect [1, 11]. The known experimental studies deal with the early phase of infarct when the vasogenic perifocal edema has not yet developed. On the other hand, a beneficial effect of dexamethasone in stroke patients has been observed many hours and even days after the stroke. Therefore, in the present investigation the effect of dexamethasone treatment on experimental brain infarcts has been studied over a long period.
Key wordsExperimental infarcts dexamethasone brain edema rCBF
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