Brain Edema pp 646-651 | Cite as

Effect of Dexamethasone on Regional Cerebral Blood Flow and on Serum Protein Extravasation in Experimental Brain Infarcts in Monkeys

  • A. Hartmann
  • K.-A. Hossmann
  • Z. Czernicki
  • L. M. Barbosa-Coutinho
  • G. Ebhardt
  • J. Menzel
Conference paper


The effect of dexamethasone on brain infarcts has been the subject of numerous clinical and experimental studies [3, 4, 7, 8]. In most experimental investigations no beneficial effect of dexamethasone has been found. However, clinical studies and practice have suggested such an effect [1, 11]. The known experimental studies deal with the early phase of infarct when the vasogenic perifocal edema has not yet developed. On the other hand, a beneficial effect of dexamethasone in stroke patients has been observed many hours and even days after the stroke. Therefore, in the present investigation the effect of dexamethasone treatment on experimental brain infarcts has been studied over a long period.

Key words

Experimental infarcts dexamethasone brain edema rCBF 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anderson DC, Cranford RE (1979) Corticosteroids in ischemic stroke. Stroke 10:68–71PubMedCrossRefGoogle Scholar
  2. 2.
    Barbosa-Coutinho LM, Hartmann A, Hossmann K-A, Rommel T (1984) Effect of dexamethasone on serum protein extravasation in experimental brain infarcts of monkey: an immunohistochemical study. Acta Neuropathol (in press)Google Scholar
  3. 3.
    Bremer AM, Yamada K, West CR (1980) Ischemic cerebral edema in primates: Effects of acetazolamide, phenytoin, sorbitol, dexamethasone, and methylprednisolone on brain water and electrolytes. Neurosurgery 6:149–154PubMedCrossRefGoogle Scholar
  4. 4.
    Fenske A, Fischer M, Regli F, Hase U (1979) The response of focal ischemic cerebral edema to dexamethasone. J Neurol 220:199–209PubMedCrossRefGoogle Scholar
  5. 5.
    Hartmann A, Menzel J, Buttinger C, Lange D, Alberti E (1981) Regional cerebral blood flow in the baboon during ischemic cerebral infarction under dexamethasone treatment. Fortschr Neurol Psychiatr 49:380–392PubMedCrossRefGoogle Scholar
  6. 6.
    Hossmann K-A, Hürter T, Oschlies U (1983) The effect of dexamethasone on serum protein extravasation and edema development in experimental brain tumors of cat. Acta Neuro-pathol(Berl) 60:223–231CrossRefGoogle Scholar
  7. 7.
    Kahn K, Pranzarone G, Newman T (1972) Dexamethasone treatment of experimental cerebral infarction. Neurology 22:406–407Google Scholar
  8. 8.
    Lee MC, Mastri AR, Waltz AG, Loewenson RB (1974) Ineffectiveness of dexamethasone treatment of experimental cerebral infarction. Stroke 5:216–225PubMedCrossRefGoogle Scholar
  9. 9.
    Pappius HM (1982) Dexamethasone and local cerebral glucose utilization in freeze-trau-matized rat brain. Ann Neurol 12:157–162PubMedCrossRefGoogle Scholar
  10. 10.
    Pappius HM, Wolfe LS (1983) Functional disturbances in brain following injury: search for underlying mechanisms. Neurochem Res 8:63–72PubMedCrossRefGoogle Scholar
  11. 11.
    Sage JI, van Uitert RL (1982) Clinical benefit of steroids in early postischemic disruption of the blood-brain barrier. Ann Neurol 12:84–85Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • A. Hartmann
    • 1
  • K.-A. Hossmann
  • Z. Czernicki
  • L. M. Barbosa-Coutinho
  • G. Ebhardt
  • J. Menzel
  1. 1.Abt. für RadiologieUniversitätsnervenklinikBonn 1Germany

Personalised recommendations