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Brain Edema pp 555-559 | Cite as

Effect of a Calcium Antagonist, Nicardipine, on Ischemic Brain Edema Formation

  • H. Johshita
  • T. Asano
  • K. Takakura

Abstract

The effects of calcium antagonists on cerebral ischemia or anoxia have been widely discussed [1, 2]. But there is some controversy about their beneficial effects. We studied the influence of a calcium antagonist [3], nicardipine, on the cortical blood flow (1CBF) and specific gravity (SG) following focal cerebral ischemia.

Key words

Calcium antagonist nicardipine cerebral blood flow hydrogen clearance specific gravity 

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References

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    Kazda S, Garthoff B, Krause HP, Schlossmann K (1982) Cerebrovascular effect of the calcium antagonistic dihydropyridine derivative nimodipine in animal experiments. Drug Res 32:331–338Google Scholar
  2. 2.
    Harris RJ, Branston NM, Symon L, Bayhan M, Watson A (1982) The effect of a calcium antagonist, nimodipine, upon physiological responses of the cerebral vasculature and its possible influence upon focal cerebral ischaemia. Stroke 13:759–764PubMedCrossRefGoogle Scholar
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    Takenaka T, Handa J (1979) Cerebrovascular effects of YC-93, a new vasodilator, in dogs, monkeys and human patients. Int J Clin Pharmacol Biopharm 17:1–11PubMedGoogle Scholar
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    Marmarou A, Poll W, Shulman K, Bhagavan H (1978) A simple gravimetric technique for measurement of cerebral edema. J Neurosurg 49:530–537PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. Johshita
    • 1
  • T. Asano
  • K. Takakura
  1. 1.Department of NeurosurgeryUniversity of Tokyo HospitalBunkyo-ku, Tokyo 113Japan

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