Quantification of Blood-Brain-Barrier Permeability Following Varying Periods of Severe Temporary Cerebral Ischemia
Ischemic brain edema follows a complex pattern: water begins to accumulate early after an ischemic insult without major disruption of the blood-brain barrier (BBB), but with time a vasogenic component is added [4, 7]. Alteration in BBB permeability is known to be faster after restoration of blood flow than in permanent ischemia . This causes an extravasation of plasma protein into the tissue and a further accumulation of water in the brain. The damage to the cerebral vessels following recirculation, as reflected by the BBB disruption, is related to the duration of the ischemic period [4, 6]. We have used an experimental model of reversible cerebral ischemia to investigate and quantify the changes in brain water and BBB permeability at the end of a fixed interval of reperfusion following different periods of ischemia.
KeywordsSpecific Gravity Brain Edema Ischemic Insult Ischemic Period Permanent Ischemia
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