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Brain Edema pp 447-453 | Cite as

Quantification of Blood-Brain-Barrier Permeability Following Varying Periods of Severe Temporary Cerebral Ischemia

  • P. Picozzi
  • N. V. Todd
  • H. A. Crockard
  • R. R. Russell

Abstract

Ischemic brain edema follows a complex pattern: water begins to accumulate early after an ischemic insult without major disruption of the blood-brain barrier (BBB), but with time a vasogenic component is added [4, 7]. Alteration in BBB permeability is known to be faster after restoration of blood flow than in permanent ischemia [4]. This causes an extravasation of plasma protein into the tissue and a further accumulation of water in the brain. The damage to the cerebral vessels following recirculation, as reflected by the BBB disruption, is related to the duration of the ischemic period [4, 6]. We have used an experimental model of reversible cerebral ischemia to investigate and quantify the changes in brain water and BBB permeability at the end of a fixed interval of reperfusion following different periods of ischemia.

Keywords

Specific Gravity Brain Edema Ischemic Insult Ischemic Period Permanent Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • P. Picozzi
    • 1
  • N. V. Todd
  • H. A. Crockard
  • R. R. Russell
  1. 1.Institute of Neurosurgery, First Medical SchoolUniversity of NaplesNaplesItaly

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