Changes in Specific Gravity of Discrete Brain Regions and Postischemic Morbidity Following Reversible and Irreversible Cerebral Ischemia in Mongolian Gerbil
The occlusion of the bilateral common carotid arteries (CCA) in Mongolian gerbil causes severe telencephalic ischemia [4, 5], and the temporary occlusion of bilateral CCA has been used as a good model for reversible and/or irreversible global cerebral ischemia . There have been no studies on the changes in water content of brain in association with the duration of ischemic period or on the relationship between the changes and neurologic deficits following transient global cerebral ischemia in this animal. In the present study we evaluated the changes in water content of four brain regions and the neurologic deficits in the same animals, and investigated the relationship between these two variables.
Key wordsCerebral ischemia Mongolian gerbil cerebral edema postischemic morbidity stroke index
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