Brain Edema pp 410-417 | Cite as

The Duration of Ischemia Influences Ischemic and Postischemic Brain Edema

  • N. V. Todd
  • P. Picozzi
  • H. A. Crockard
  • R. R. Russell
Conference paper


The development and resolution of ischemic brain edema is a complex problem. During ischemia the failure of cellular metabolism leads to a failure of ionic homeostasis and an increase in brain osmolality, and water tends to move into the brain to balance this. The amount of water accumulating during ischemia depends upon the level of flow during ischemia [3, 17], its duration [10, 12], and whether the ischemia is complete or incomplete [16]. Reestablishment of blood flow to an ischemic region may lead to an increase in brain water, occurring either immediately [2, 9] or later, in association with breakdown of the blood-brain barrier (BBB) [10].


Cerebral Blood Flow Specific Gravity Brain Edema Hydrogen Clearance Cortical Cerebral Blood Flow 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • N. V. Todd
    • 1
  • P. Picozzi
  • H. A. Crockard
  • R. R. Russell
  1. 1.Institute of NeurologyThe National Hospitals for Nervous DiseasesLondonGreat Brain

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