Brain Edema pp 392-395 | Cite as

Role of Prostaglandins in Experimental Ischemic Brain Edema in Hypertensive Rats: TXA2 Priority in Hypertensive Rats

  • S. Sugimoto
  • A. Terashi
  • Y. Katayama
  • M. Mizoguchi
  • T. Soeda
  • K. Inamura
  • S. Suzuki
  • J. Shimizu
  • H. Memezawa
  • H. Minamizawa
Conference paper

Abstract

Hypertensive rats are known to be more susceptible to ischemic insults than normotensive rats [1, 2], but the reason for this is still obscure.

Keywords

Ischemia EDTA Lactate Prostaglandin Indomethacin 

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References

  1. 1.
    Fujishima M, Tamaki K, Nakatomi Y, Ishithuka T, Nakagawara K, Omae T (1980) Experimental cerebral ischemia in spontaneously hypertensive rats (SHR); importance of degree of hypertension. Stroke 11:612–616PubMedCrossRefGoogle Scholar
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    Katayama Y, Terashi A, Sugimoto S, Inamura K, Suzuki S, Sekiguchi F, Akashi A (1984) Experimental cerebral ischemia after bilateral common carotid artery ligation in SHRSP, SHRSR and Wistar rats. Brain Nerve 36:1069–1075PubMedGoogle Scholar
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    Needleman P, Wyche A, Raz A (1979) Platelet and blood vessel arachidonate metabolism and interactions. J Clin Invest 63:345–349PubMedCrossRefGoogle Scholar
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    Fujishima M, Omae T (1976) Carotid back pressure following bilateral carotid occlusion in normotensive and spontaneously hypertensive rats. Experimentia 32:1021–1022CrossRefGoogle Scholar
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    Terashi A, Katayama Y, Sugimoto S, Soeda T, Inamura K, Shimizu J, Suzuki S, Mizoguchi M, Okamoto A, Nagazumi A (1983) Pathogenesis and treatment of cerebral edema. Prog Med 3:507–516Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • S. Sugimoto
    • 1
  • A. Terashi
  • Y. Katayama
  • M. Mizoguchi
  • T. Soeda
  • K. Inamura
  • S. Suzuki
  • J. Shimizu
  • H. Memezawa
  • H. Minamizawa
  1. 1.2nd Dept. of Internal MedicineNippon Medical SchoolChiyoda-ku, Tokyo 102Japan

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