Brain Edema pp 258-262 | Cite as

Simultaneous Topographic Analysis of Brain Edema, Parenchymal Energy Metabolisms (NAD/NADH Redox State, Reduced Cytochrome aa3, ATP), and Intracellular Calcium During Cerebral Ischemia

  • N. Hayashi
  • T. Tsubokawa
  • S. Kimura
  • Y. Makiyama
  • M. Toeda
Conference paper

Abstract

In cases of brain edema caused by cerebral ischemic insult it has been documented that cytotoxic edema occurs before vasogenic edema [3, 8] and that both types promote the development of secondary brain edema with concomitant metabolic changes and microcirculatory disturbances [5]. As a consequence, studies of brain edema have focused on the correlations between metabolic changes, intracellular ion changes, and vasogenic edema following cerebral ischemia. These parameters were simultaneously subjected to topographic analysis with reference to the same sliced brain by a laser photographic, computer-assisted method developed in our laboratory in collaboration with NIIC Laser Co. (4–16–13 Nishi Azabu Minato-ku, Tokyo, Japan). The block diagram is shown in Fig. 1.

Key words

Cerebral ischemia brain edema intracellular Ca mitochondrial energy metabolism laser photospectrometric analysis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • N. Hayashi
    • 1
  • T. Tsubokawa
  • S. Kimura
  • Y. Makiyama
  • M. Toeda
  1. 1.Department of NeurosurgeryNihon UniversityItabashi-ku, Tokyo 173Japan

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