Brain Edema pp 215-223 | Cite as

Disturbances of Cerebral Arterial Permeability and Blood-Brain Barrier Following Experimental Subarachnoid Hemorrhage

  • T. Sasaki
  • N. F. Kassell
  • M. Yamashita
  • S. Fujiwara
  • M. Zuccarello


Breakdown of the blood-brain barrier (BBB) following experimental subarachnoid hemorrhage (SAH) is currently controversial. Trojanowsky [1] has reported an early profound increase in capillary permeability in cats suffering from SAH. Shigeno et al. [2] have observed extravasation of Evans blue dye only in cats with both SAH and arterial hypertension, while Peterson and Cardoso [3] have recently reported that no demonstrable BBB lesions were observed when cats were rendered hypertensive after SAH.

Key words

Blood-brain barrier subarachnoid hemorrhage vasospasm intracranial pressure computerized tomography 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • T. Sasaki
    • 1
  • N. F. Kassell
  • M. Yamashita
  • S. Fujiwara
  • M. Zuccarello
  1. 1.Department of Neurological SurgeryUniversity of VirginiaCharlottesvilleUSA

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