Abstract
Twenty male Wistar rats weighing approximately 300 g were used. Under ketamine anesthesia (150mg/kg body weight) the animals were allowed to breathe spontaneously and underwent cannulation of the right femoral artery and vein, which allowed us to monitor physiological parameters and to administer drugs. Body temperature was monitored and kept at 37.5 °C. Once the physiological parameters were within normal ranges the left MCA was exposed according to the procedure of Albanese et al. [1] and occluded by bipolar coagulation. The animals were sacrificed 10, 30, 60, and 180 min after occlusion of the MCA.
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© 1985 Springer-Verlag Berlin Heidelberg
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Cervós-Navarro, J., Nakagawa, Y., Sampaolo, S. (1985). Early Changes in Blood-Brain Barrier Permeability After MCA Occlusion in Rats. In: Inaba, Y., Klatzo, I., Spatz, M. (eds) Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70696-7_30
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DOI: https://doi.org/10.1007/978-3-642-70696-7_30
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