Disintegration of Orthogonal Arrays in Perivascular Astrocytic Processes as an Early Event in Acute Global Ischemia
Orthogonal arrays or square assemblies of intramembrane particles as revealed by a freeze-fracture technique are a distinctive specialization of the plasmalemma of certain types of cells . In the mammalian central nervous system they have been observed in the astrocytes and ependymal cells. Although the function of membrane specialization has not yet been elucidated, a preponderance of the structure in the astrocytic processes facing small parenchymal vessels and subarachnoid spaces has led to the assumption that they might be involved in transport into and out of these compartments . In addition, rapid disappearance of orthogonal arrays after circulatory arrest has recently been reported in the astrocytic membrane of the mouse brain .
Key wordsAstrocyte brain ischemia orthogonal arrays square assemblies freeze-fracture
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