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Brain Edema pp 155-158 | Cite as

Disintegration of Orthogonal Arrays in Perivascular Astrocytic Processes as an Early Event in Acute Global Ischemia

  • M. Suzuki
  • Y. Iwasaki
  • H. Arai
  • T. Yamamoto
  • H. Konno
  • T. Yoshimoto
  • J. Suzuki
Conference paper

Abstract

Orthogonal arrays or square assemblies of intramembrane particles as revealed by a freeze-fracture technique are a distinctive specialization of the plasmalemma of certain types of cells [3]. In the mammalian central nervous system they have been observed in the astrocytes and ependymal cells. Although the function of membrane specialization has not yet been elucidated, a preponderance of the structure in the astrocytic processes facing small parenchymal vessels and subarachnoid spaces has led to the assumption that they might be involved in transport into and out of these compartments [1]. In addition, rapid disappearance of orthogonal arrays after circulatory arrest has recently been reported in the astrocytic membrane of the mouse brain [4].

Key words

Astrocyte brain ischemia orthogonal arrays square assemblies freeze-fracture 

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References

  1. 1.
    Anders JJ, Brightman MW (1970) Assemblies of particles in the cell membranes of developing, mature and reactive astrocytes. J Neurocytol 8:777–795CrossRefGoogle Scholar
  2. 2.
    Hertz L (1981) Features of astrocytic function apparently involved in the response of central nervous tissue to ischemia-hypoxia. J Cereb Blood Flow Metab 1:143–153PubMedCrossRefGoogle Scholar
  3. 3.
    Landis DMD, Reese TS (1974) Arrays of particles in freeze-fractured astrocytic membrane. J Cell Biol 60:316–320PubMedCrossRefGoogle Scholar
  4. 4.
    Landis DMD, Reese TS (1981) Astrocytic membrane structure: Changes after circulatory arrest. J Cell Biol 88:660–663PubMedCrossRefGoogle Scholar
  5. 5.
    Suzuki M (1984) Disintegration of orthogonal arrays in perivascular astrocytic processes as an early event in acute global ischemia. Brain Res 300:141–145PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • M. Suzuki
    • 1
  • Y. Iwasaki
  • H. Arai
  • T. Yamamoto
  • H. Konno
  • T. Yoshimoto
  • J. Suzuki
  1. 1.Divisions of Neurosurgery and Neuropathology, Institute of Brain DiseasesTohoku University School of MedicineSendai City 980Japan

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