Abstract
The finding that increased cerebrovascular permeability in acute hypertension is associated with reduction of endothelial surface charge [3] suggests the occurrence of alterations in factors contributing to charge. About 50% of the net negative charge on endothelium is thought to be due to sialyl residues [2]. Since no published reports are available of the distribution of sialyl and other monosaccharide residues on cerebral endothelium this ultrastructural study was undertaken.
This work was supported by the Heart and Stroke Foundation of Ontario.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Butters TD, Hughes RC (1978) Lectin binding to mosquito Aedes aegyptii and human KB cells: structural comparisons of membrane oligosaccharides. Carbohyd Res 61:159–168
Danon D, Skutelsky E (1976) Endothelial surface charge and its possible relationship to thrombogenesis. Ann NY Acad Sci 275:47–63
Nag S (1984) Cerebral endothelial surface charge in hypertension. Acta Nauropathol (Berl) 63:276–281
Nag S, Robertson DM, Dinsdale HB (1979) Quantitative estimate of pinocytosis in experimental acute hypertension. Acta Neuropathol (Berl) 46:107–116
Pena SDJ, Gordon BB, Karpati G, Carpenter S (1981) Lectin histochemistry of human skeletal muscle. J Histochem Cytochem 29:542–546
Pino RM (1984) Ultrastructural localization of lectin receptors on the bone marrow sinusoidal endothelium of the rat. Am J Anat 169:259–272
Schulte BA, Spicer SS (1983) Histochemical evaluation of mouse and rat kidneys with lectin-horseradish peroxidase conjugates. Am J Anat 168:345–362
Simionescu M, Simionescu N, Palade GE (1982) Differentiated microdomains on the luminal surface of capillary endothelium: distribution of lectin receptors. J Cell Biol 94:406–413
Vierbuchen M, Klein PJ (1983) Histochemical demonstration of neuraminidase effects in pneumococcal meningitis. Lab Invest 48:181–186
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Nag, S. (1985). Distribution of Lectin Receptors on Cerebral Endothelium. In: Inaba, Y., Klatzo, I., Spatz, M. (eds) Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70696-7_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-70696-7_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70698-1
Online ISBN: 978-3-642-70696-7
eBook Packages: Springer Book Archive