Advertisement

Cell Interactions in the Morphogenesis of the Neural Crest

  • D. F. Newgreen
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

The neural crest of vertebrate embryos is formed by epithelial cells lying between the neural plate ectoderm and the more lateral epidermal ectoderm. As the neural plate folds to form the neural tube, the neural crest is brought to a dorso-medial position. At around this stage the neural crest population starts to transform from an epithelium to mesenchyme. These mesenchymal cells then disperse, initially into adjacent spaces filled with extracellular matrix (ECM). In the following stages, the cells of this lineage localize at discrete, often distant sites where overt differentiation takes place (see Le Douarin 1982). The orderly execution of this complex pattern of morphogenesis clearly rests on an interaction of these cell with their cellular and non-cellular environment. Some of the interactions that control the development of this system are discussed below, using the avian embryo as a model.

Keywords

Neural Crest Neural Crest Cell Crest Cell Neural Plate Orderly Execution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson CB, Meier S (1982) Effect of hyaluronidase treatment on the distribution of cranial neural crest cells in the chick embryo. J Exp Zool 221: 329–335PubMedCrossRefGoogle Scholar
  2. Le Douarin NM (1982) The neural crest. Cambridge University Press, CambridgeGoogle Scholar
  3. Newgreen DF (1982) Adhesion to extracellular materials by neural crest cells at the stage of initial migration. Cell Tissue Res 227: 297–317PubMedCrossRefGoogle Scholar
  4. Newgreen DF (1984) Spreading of explants of embryonic chick mesenchymes and epithelia on fibronectin and laminin. Cell Tissue Res 236: 265–277PubMedCrossRefGoogle Scholar
  5. Newgreen DF, Gibbins I (1982) Factors controlling the time of onset of the migration of neural crest cells in the fowl embryo. Cell Tissue Res 224: 145–160PubMedCrossRefGoogle Scholar
  6. Newgreen DF, Gooday D (1985) Control of the onset of migration of neural crest cells in avian embryos. Role of Ca2+-dependent cell adhesions. Cell Tissue Res 239: 329–336PubMedCrossRefGoogle Scholar
  7. Newgreen DF, Thiery JP (1980) Fibronectin in early avian embryos: Synthesis and distribution along migration pathways of neural crest cells. Cell Tissue Res 221: 269–291Google Scholar
  8. Newgreen DF, Gibbins IL, Sauter J, Wallenfels B, Wutz R (1982) Ultrastructural and tissue culture studies on the role of fibronectin, collagen and glycosaminoglycans in the migration of neural crest cells in the fowl embryo. Cell Tissue Res 221: 521–549PubMedCrossRefGoogle Scholar
  9. Takeichi M, Ozaki HS, Tokunaga K, Okada TS (1979) Experimental manipulations of cell surface to affect cellular recognition mechanisms. Dev Biol 70: 195–205PubMedCrossRefGoogle Scholar
  10. Thiery JP, Duband JL, Rutishauser U, Edelman GM (1982) Cell adhesion molecules in early chicken morphogenesis. Proc Natl Acad Sci USA 79: 6737–6741PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. F. Newgreen
    • 1
  1. 1.Abteilung BiochemieMax-Planck-Institut für EntwicklungsbiologieTübingenGermany

Personalised recommendations