Modulation of a Potassium Channel in Aplysia Sensory Neurons: Role of Protein Phosphorylation

  • J. S. Camardo
  • M. J. Shuster
  • S. A. Siegelbaum
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Serotonin (5-HT) produces a slow depolarizing postsynaptic potential in the mechanoreceptor sensory neurons of the abdominal ganglia of the marine snail Aplysia. This slow EPSP is accompanied by a decrease in resting membrane conductance, a broadening of the action potential duration, and an increase in transmitter release from the sensory neuron terminals. The increase in transmitter release is thought to underlie behavioral sensitization of the gill-withdrawal reflex (Kandel and Schwartz 1982). Voltage clamp experiments have shown that the primary effect of serotonin in the sensory neurons is to decrease a specific outward potassium membrane current (S current) that is distinct from the previously identified K+ currents in molluscan neurons (Klein et al. 1982).


Sensory Neuron Single Channel Behavioral Sensitization Single Channel Conductance Single Channel Current 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. S. Camardo
  • M. J. Shuster
  • S. A. Siegelbaum
    • 1
    • 2
  1. 1.Department of Pharmacology, Center for Neurobiology and Behavior, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Department of Physiology, Center for Neurobiology and Behavior, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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