Abstract
In its distinctive form and specialized function the postsynaptic apparatus of the neuromuscular junction has many of the characteristics of an organelle; a tissue-specific one to be sure. Like other organelles, the junctional apparatus is formed and maintained by genetically programmed mechanisms which are modulated by environmental cues. For example, embryonic myotubes and denervated adult fibers assemble synaptic specializations under the influence of nerve terminals, and once innervated, a muscle will not easily form additional synapses. Thus, regulatory signals must pass between nerve and muscle to insure the formation and proper maintenance of the synapse. Recognition of the similarities between the synapse and other organelles has prompted us to consider the possibility that the genetic expression of components of the synapse is regulated by a common and synapse specific mechanism.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berg DK, Hall ZW (1975) Loss of a-bungarotoxin from junctional and extrajunctional acetylcholine receptors in rat diaphragm in vivo and organ culture. J Physiol (Lond) 252: 771–789
Bloch RJ, Hall ZW (1983) Cytoskeletal components of the vertebrate neuromusclular junction:
Vinculin, a-actinin, and filamin. J Cell Biol 97:217–223
Buc-Caron MH, Nystrom P, Fischbach GD (1983) Induction of acetylcholine receptor synthesis and aggregation: partial purification of low-molecular-weight activity. Dev Biol 95: 378–386
Caravatti M, Minty A, Robert B, Montarras D, Weydert A, Cohen A, Daubas P, Buchingham M (1982) Regulation of muscle gene expression: the accumulation of messenger RNA’s coding for muscle-specific proteins during myogenesis in a mouse cell line. J Mol Biol 160: 59–76
Couteaux R (1973) Motor end plate structure: In: Bourne GH (ed) The structure and function of muscle, vol II. Academic, New York, p 483
Covault J, Sanes JR (1985) Neural cell adhesion molecule ( N-CAM) accumulates in denervated and paralyzed skeletal muscles. Proc Natl Acad Sd USA 82: 4544–4548
Fambrough DM (1979) Control of acetylcholine receptors in skeletal muscle. Physiol Rev 59:165– 226
Hall ZW, Roizin MP, Gu Y, Gorin PD (1983) A developmental change in the immunological properties of the acetylcholine receptors at the rat neuromuscular junction. Cold Spring Harbor Symp Quant Biol 40: 263–274
Klarsfeld A, Devillers-Thiery A, Giraudat J, Changeux J-P (1984) A single gene codes for the nicotinic acetylcholine receptor a-subunit in Torpedo marmorata: Structural and developmental implications. EMBO J 3: 35–41
La Polla RJ, Mixter Mayne K, Davidson N (1984) Isolation and characterization of a cDNAclone for the complete protein coding region of the 6 subunit of the mouse acetylcholine receptor. Proc Natl Acad Sci USA 81: 7970–7974
Massoulie J, Bon S (1982) The molecular forms of cholinesterase and acetylcholinesterase in vertebrates. Annu Rev Neurosci 5: 57–106
Merlie JP, Sanes JR (to be published) Acetylcholine receptor mRNA is concentrated in synaptic regions of adult muscle fibres Merli JP, Sebbane R, Gardner S, Lindstrom J (1983a) cDNA clone for the a subunit of the acetylcholine receptor from the mouse muscle cell line BC3H-1. Proc Natl Acad Sci USA 80:3845– 3849
Merlie JP, Sebbane R, Gardner S, Olson E, Lindstrom J (1983b) The regulation of acetylcholine receptor expression in mammalian muscle. Cold Spring Harbor Symp Quant Biol 48: 135–145
Merlie JP, Isenberg K, Russell S, Sanes JR (1984) Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe. J Cell Biol 99: 332–335
Nef P, Mauron A, Stalder R, Alliod C, Ballivet M (1984) Structure, linkage, and sequence of the two genes encoding the 8 and y subunits of the nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 81: 7975: 7979
Noda M, Furutani Y, Takahashi H, Toyosato M, Tanabe T, Shimizu S, Kikyotani S, Kayano T, Hirose T, Inayama S, Numa S (1983) Cloning and sequence analysis of calf cDNA and human genomic DNA encoding a-subunit precursor of muscle acetylcholine receptor. Nature 305: 818–823
Olson EN, Glaser L, Merlie JP, Sebbane R, Lindstrom J (1983) Regulation of surface expression of acetylcholine receptors in response to serum and cell growth in the BC3H-1 mouse cell line. J Biol Chem 258: 13946–13953
Salpeter MM, Harris RJ (1983) Distribution and turnover rate of acetylcholine receptors throughout the junction folds at a vertebrate neuromuscular junction. J Cell Biol 96: 1791–1785
Sanes JR, Feldman DH, Cheney JM, Lawrence JC Jr (1984) Brain extract induces synaptic characteristics in the basal lamina of cultured myotubes. J Neurosci 4: 464–473
Shibahara S, Kubo T, Perski HS, Takahashi H, Noda M, Numa S (1985) Cloning and sequence analysis of human genomic DNA encoding y subunit precursor of muscle acetylcholine receptor. Eur J Biochem 146: 15–22
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Merlie, J.P., Sanes, J.R. (1986). Regulation of Synapse-specific Genes. In: Montalcini, R.L., Calissano, P., Kandel, E.R., Maggi, A. (eds) Molecular Aspects of Neurobiology. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70690-5_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-70690-5_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70692-9
Online ISBN: 978-3-642-70690-5
eBook Packages: Springer Book Archive