The Interaction of Neuromuscular Blocking Agents With Human Cholinesterases and Their Binding to Plasma Proteins

  • F. F. Foldes
  • A. Deery
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 79)


The interactions of neuromuscular (NM) blocking agents (NMBA) with cholinesterases (ChE) have inportant pharmacologic and clinical implications. Some of the ester type NMBA, e.g., succinylcholine chloride (suxamethonium; SCh), suxethonium bromide, are hydrolyzed by human plasma butyrylcholinesterase (EC; BuChE) (Tsuji and Foldes 1953; Foldes et al. 1956). Their hydrolysis rate in most other mammalian plasmas is much lower than in human plasma (Tsuji and Foldes 1953). In vivo inhibition of plasma BuChE will increse the intensity and duration of action of hydrolyzable NMBA.


Neuromuscular Blocking Agent Muscle AChE Succinylcholine Chloride Mammalian Plasma Pipecuronium Bromide 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • F. F. Foldes
  • A. Deery

There are no affiliations available

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