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On the Comparative Sensitivity of Acetylcholine Receptors of Various Groups of Skeletal Muscles to Neuromuscular Blocking Agents

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New Neuromuscular Blocking Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 79))

Abstract

It is well known that the comparative sensitivity of acetylcholine receptors to neuromuscular blocking agents is different for various groups of muscles. Thus, for instance, tubocurarine causes relaxation, first, of the cervical and facial muscles, then, of the muscles of the torso and limbs, and last, of respiratory muscles (intercostal and diaphragm). Often, this is considered to be true of other neuromuscular blocking agents, although the data on comparative sensitivity of end-plate acetylcholine receptors to other drugs are rather discrepant. The latter is sometimes believed to be related to diverse influences of different factors on the sensitivity of acetylcholine receptors to neuromuscular blocking agents, including the type of anesthesia, structure of skeletal muscles, their temperature, blood circulation, volume of hemorrhage during the operation, acid-base equilibrium, etc.

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Authors
  1. D. A. Kharkevich
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  2. V. P. Fisenko
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Editors and Affiliations

  1. Department of Pharmacology, Academy of Medical Sciences First Medical Institute, 2/6 Pirogovskaya Street, Moscow, II9435, USSR

    Dimitry A. Kharkevich M.D., D. Sc. (Professor and Chairman of the Department of Pharmacology Academician of the USSR) (Professor and Chairman of the Department of Pharmacology Academician of the USSR)

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Kharkevich, D.A., Fisenko, V.P. (1986). On the Comparative Sensitivity of Acetylcholine Receptors of Various Groups of Skeletal Muscles to Neuromuscular Blocking Agents. In: Kharkevich, D.A. (eds) New Neuromuscular Blocking Agents. Handbook of Experimental Pharmacology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70682-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-70682-0_6

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