For several years, anesthesiologists have stated that two new types of neuromuscular blocking drugs (curare-like drugs, muscle relaxants) are needed in clinical anesthesia (Savarese and Kitz 1975). One type of neuromuscular blocking drug would be one that is nondepolarizing with a very rapid onset time (time from muscle relaxant administration until peak effect) and short duration of action, similar to that of succinylcholine, but without the latter drug’s well-known side effects and complications. BW 785U seemed to meet these qualifications (Savarese et al. 1980). However, because of significant histamine release (Rosow et al. 1980), clinical trials with BW 785U were terminated. Thus, the goal of developing this type of neuromuscular blocking drug for clinical anesthesiology has yet to be realized.
KeywordsEndotracheal Intubation Neuromuscular Blockade Neuromuscular Blocking Drug High Pressure Liquid Chromatography Method Prolonged Paralysis
Unable to display preview. Download preview PDF.
- Crul JF, Booij LHDJ (1980) First clinical experience of ORG NC45. Br J Anaesth 5249S-52SGoogle Scholar
- Foldes FF, Yun H, Radnay PH, Badola RP, Kaplan R, Nagashima H (1981) Antagonism of the neuromuscular effect of ORG-NC45 by edrophonium. Anesthesiology 55:A201 (abstract)Google Scholar
- Morris RB, Wilkinson PL, Miller RD, Cahalan M, Quasha A, Robinson SL (1981 a) Cardiovascular effects of ORG NC45 (Nocuron™) in patients undergoing coronary artery bypass grafting. Anesthesiology 55:A205 (abstract)Google Scholar
- Nagashima H, Kaplan R, Radnay P, Yun H, Duncalf D, Foldes FF (1981) Relaxation with ORG NC45 during neurolept anesthesia. Anesthesiology 54:A200 (abstract)Google Scholar
- Sohn YJ, Scaf AHJ, Bencini A, Gregoretti S, Agoston S (1982) The comparative pharmacokinetics of vecuronium (ORG NC45) and pancuronium in man. Fed Proc 41:1336 (abstract)Google Scholar