Abstract
Muscle relaxants belong to the basic anesthetic drugs and it is quite understandable that newer compounds have come into being. Among these drugs, steroid derivatives have an important place and, besides pancuronium, many similarly structured muscle relaxants have been tried in the past few years (Sugrue et al. 1975; Bowman 1980; Tuba 1980).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alánt O, Darvas K, Pulay I (1980) First clinical experience with a new neuromuscular blocker pipecuronium bromide. Arzneimittelforsch 20:374–379
Alyantdin RN, Buyanon VV, Fisenco VP, Lemina E, Muratov VK, Samoilov DN, Shorr VA (1980) On some properties of a new steroidal curare-like compound pipecuronium bromide. Arzneimittelforsch 30:355–357
Barankay A (1980) Circulatory effects of pipecuronium bromide during anesthesia of patients with severe valvular and ischemic heart diseases. Arzneimittelforsch 30:386–389
Bodrogi L, Fehér T, Váradi A, Vereckey L (1980) Pharmacokinetics of pipecuronium bromide in the rat. Arzneimittelforsch 30:366–370
Boros M, Szenohradszky J, Marosi GY, Tóth J (1980) Comparative clinical study of pipecuronium bromide and pancuronium bromide. Arzneimittelforsch 30:389–393
Bowman WC (1980) A new non-depolarizing neuromuscular blocking drug. Trends Pharm Sci 3:263–266
Brand L (1978) Hemodynamic changes due to anesthesia using curare and curarizing agent. In: Hemodynamic changes in anesthesia, vol 3. Academic Européene d’Anesthesiolo-gie, Paris, pp 1123–1135
Bunjatjan AA, Miheev VI (1980) Clinical experience with a new steroid muscle relaxant: pipecuronium bromide. Arzneimittelforsch 30:383–385
Buzello W, Agoston S (1978) Pharmacokinetics of pancuronium in patients with normal and impaired renal function. Anaesthesist 27:291–297
Coleman AJ, Downing JW, Leary WP, Moyes DG, Styles M (1972) The immediate cardiovascular effects of pancuronium alcuronium and tubocurarine in man. Anesthesia 27:415–421
Fahey MR, Morris RB, Miller RD, Nguyen TL, Upton RA (1981) Pharmacokinetics of Org NC 45 (Norcuron) in patients with and without renal failure. Br J Anaesth 53:1049–1054
Foldes FF, Chaudry J, Ohta Y et al. (1981) The influence of stimulation parameters on the potency and reversibility of neuromuscular blocking agents. J Neural Transm 52:227–249
Kárpáti E, Biró K (1980) Pharmacological study of a new competitive neuromuscular blocking steroid, pipecuronium bromide. Arzneimittelforsch 30:346–354
Kelman GR, Kennedy BR (1971) Cardiovascular effects of pancuronium in man. Br J Anaesth 43:335–356
Krieg N, Crull JF, Booij LMD (1980) Relative potency of Org NC 45, pancuronium, alcuronium and tubocurarine in anesthetized man. Br J Anaesth 52:783–794
McLoad K, Watson MJ, Rawlins MD (1976) Pharmacokinetics of pancuronium in patients with normal and impaired renal function. Br J Anaesth 48:341–349
Pulay I, Alánt O, Darvas K, Weltner J, Zétény ZS (1980) Respiration paralysing and circulatory effects of a new non-depolarizing relaxant, pipecuronium bromide, in anesthetized dogs. Arzneimittelforsch 30:358–360
Somogyi AA, Shanks CA, Triggs EJ (1976) Clinical pharmacokinetics of pancuronium bromide. Eur J Clin Pharmacol 10:367–372
Somogyi AA, Shanks CA, Triggs EJ (1977) Disposition kinetics of pancuronium bromide in patients with total biliary obstruction. Br J Anaesth 49:1103–1107
Stanski DR, Sneider LB (1979) Pharmacokinetics and dynamics of muscle relaxants. Anesthesiology 51:103–105
Stoelting RK (1972) The hemodynamic effects of pancuronium and d-tubocurarine in anesthetized patients. Anesthesiology 36:612–618
Sugrue MF, Duff N, McInderwar J (1975) On the pharmacology of Org 6368 [2β,16β-diperidino-5α-androstan-3α-ol acetate dimethobromide], a new steroidal neuromuscular blocking agent. J Pharm Pharmacol 27:721–727
Szabó G, Tassonyi E (1981) Determination of pipecuronium bromide, a new non-depolarizing neuromuscular blocking agent, in human serum. Arzneimittelforsch 31:1013–1015
Tassonyi E, Szabó G (1977) Correlation entre le bloc n-m et taux serique du pancuronium. Central European Anaesthesia Congress, Genova, p 3351
Tassonyi E, Szabó G (1981) Pharmakokinetische und pharmakodynamische Untersuchungen mit einem neuen steroidartigen Muskelrelaxans. In: Haid HB, Mitterschiffthaler G (eds) Zentraleuropäischer Anaesthesiekongreß 2. Springer, Berlin Heidelberg New York (Anaesthesiology and intensive care medicine, vol 140)
Tassonyi E, Szabó G, Vereckey L (1980) Pharmacokinetics of pipecuronium bromide in patients with renal failure. In: Rügheimer E, Wawersik J, Zindler M (eds) 7th World congress of anaesthesiologists. Excerpta Medica, Amsterdam, p 168 (International congress series, no 533)
Tassonyi E, Szabó G, Vereckey L (1981) Pharmacokinetics of pipecuronium bromide, a new non-depolarizing neuromuscular blocking agent, in humans. Arzneimittelforsch 31:1754–1756
Tuba Z (1980) Synthesis of 2β,16β-bis[4′-dimethyl-1-piperazino]-3α,17β-diacetoxy-5α-androstane di-bromide and related compounds. Arzneimittelforsch 30:342–345
Westra P, Houwertjes MC, DeLange AR, Scaf AH, Hindriks FR, Agoston S (1980) Effect of experimental cholestasis on neuromuscular blocking drugs in cats. Br J Anaesth 52:747–756
Wittek L, Gecsényi M, Barna B, Hargitay Z, Adorján K (1980) Report on clinical test of pipecuronium bromide. Arzneimittelforsch 30:379–383
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tassonyi, E., Szabó, G., Vimláti, L. (1986). Pipecuronium Bromide (Arduan). In: Kharkevich, D.A. (eds) New Neuromuscular Blocking Agents. Handbook of Experimental Pharmacology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70682-0_27
Download citation
DOI: https://doi.org/10.1007/978-3-642-70682-0_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70684-4
Online ISBN: 978-3-642-70682-0
eBook Packages: Springer Book Archive