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New Neuromuscular Blocking Agents pp 499–518Cite as

Dioxonium

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 79))

Abstract

The neuromuscular blocking agent, dioxonium, was synthesized by dimerizing the structure of cholinomimetic compounds. This procedure is known to lead to the loss of muscarinomimetic properties and the appearance of a pronounced blocking activity with respect to cholinoreceptors of skeletal muscles (Bovet et al. 1951). Imbretil, containing two carbachol molecules connected by six methylene groups, also fails to exert cholinomimetic effects characteristic of carbachol, but shows a strong and protracted neuromuscular blocking effect (Klupp et al. 1953). This approach has proved to be useful in the case of acetylcholine derivatives containing a dioxolan moiety, e.g., F-2268 (compound 1), showing strong muscarinomimetic activity (Fourneau et al. 1944).

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Authors
  1. A. A. Ķimenis
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Editors and Affiliations

  1. Department of Pharmacology, Academy of Medical Sciences First Medical Institute, 2/6 Pirogovskaya Street, Moscow, II9435, USSR

    Dimitry A. Kharkevich M.D., D. Sc. (Professor and Chairman of the Department of Pharmacology Academician of the USSR) (Professor and Chairman of the Department of Pharmacology Academician of the USSR)

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© 1986 Springer-Verlag Berlin Heidelberg

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Ķimenis, A.A. (1986). Dioxonium. In: Kharkevich, D.A. (eds) New Neuromuscular Blocking Agents. Handbook of Experimental Pharmacology, vol 79. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70682-0_22

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  • DOI: https://doi.org/10.1007/978-3-642-70682-0_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70684-4

  • Online ISBN: 978-3-642-70682-0

  • eBook Packages: Springer Book Archive

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