Advertisement

The Derivatives of α-Truxillic Acid

  • D. A. Kharkevich
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 79)

Abstract

The study of structure-activity relationships in the series of truxillic acid (1,3-di-phenylcyclobutane-2,4-dicarboxylic acid) derivatives prompted the evaluation of the optimal structures of the cationic centers and of the interonium part of the molecules. The derivatives of 03b1-truxillic acid basic esters and amides with n = 3 and 4 and with bis-N-methyl (or ethyl)piperidinium, bis-N-methyl (or ethyl)pyr-rolidinium, bis-N-methyldiethylammonium or bistriethylammonium groups seemed most interesting for neuromuscular blocking drug design (see Tables 2, 3, 7, 8 in Chap. 13).

Keywords

Neuromuscular Blocking Neuromuscular Transmission Neuromuscular Blocking Agent Zona Fasciculata Zona Reticularis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blackman JG (1963) Stimulus frequency and neuromuscular block. Br J Pharmacol 20:5–16Google Scholar
  2. Gallager CH (1960) The effect of pyrrolizidine alkaloids on liver enzyme system. Biochem Pharmacol 3:220–231CrossRefGoogle Scholar
  3. Dozortseva PM (1956) On the pharmacology of alkaloids from Delphinium elatum (elatinum and condelphinum) (in Russian). Farmakol Toksikol 3:42–48Google Scholar
  4. Dozortseva PM, Mashkovsky MD (1951) On comparative pharmacology of alkaloids del-seminum and delsinum (in Russian). Farmakol Toksikol 4:49–54Google Scholar
  5. Kharkevich DA (1965) On pharmacological properties of a new curare-like drug anatruxo-nium (in Russian). Farmakol Toksikol 3:305–309Google Scholar
  6. Kharkevich DA On pharmacological properties of a new curare-like drug anatruxo-nium (in Russian). or (1966) Fed Proc 25:T521-T523Google Scholar
  7. Kharkevich DA (1966) On the pharmacology of a new nondepolarizing neuromuscular blocking agent cyclobutonium (in Russian). Farmakol Toksikol 1:47–53Google Scholar
  8. Kharkevich DA (1969) Farmakologiya kurarepodobnykh sredstv (Pharmacology of curare-like agents). Meditsina, MoscowGoogle Scholar
  9. Kharkevich DA (ed) (1970) Novye kurarepodobnye i ganglioblokiruyushchie sredstva (New curare-like and ganglion-blocking agents). Meditsina, MoscowGoogle Scholar
  10. Kharkevich DA (ed) (1973) Uspekhi v sozdanii novykh lekarstvennykh sredstv (Advances in drug research). Meditsina, Moscow, pp 138–187Google Scholar
  11. Kharkevich DA (ed) (1983) Novye miorelaksanty (New muscle relaxants). Meditsina, MoscowGoogle Scholar
  12. Kharkevich DA, Kravchuk LA (1961) On the pharmacology of a new curare-like agent truxilonium (in Russian). Farmakol Toksikol 3:318–324Google Scholar
  13. Kharkevich DA, Skoldinov AP, Arendaruk AP, Kozakova TP, Muratov VK (1974) Ana-truxonium — a new curare-like drug of nondepolarizing action (in Russian). Khim-Farm Zh 4:56–62Google Scholar
  14. Kharkevich DA, Skoldinov AP, Arendaruk AP, Kozakova TP, Egorov NV, Astashina IA, Gurevich GI, Shmaryan MI, Maisky VV (1977) Cyclobutonium — a new domestic curare-like drug (in Russian). Khim-Farm Zh 2:145–150Google Scholar
  15. Korobov NV (1978) Issledovanie khronicheskoi toksichnosti novykh kurarepodobnykh sredstv (Chronic toxicological study of new curare-like agents). Cand Med Sci Thesis, First Medical Institute, MoscowGoogle Scholar
  16. Lemina, EYU (1978) Farmakologiya novykh kurarepodobnykh sredtsv dipironiya i ami-doniya (Pharmacology of new curare-like drugs). Cand Med Sci Thesis, First Medical Institute, MoscowGoogle Scholar
  17. Lepakhin VP (1970) Sensitivity of different muscles to alpha-truxillic acid derivatives (in Russian). In: Kharkevich DA (ed) Novye kurarepodobnye i ganglioblokiruyushchie sredstva (New curariform and ganglion-blocking agents). Meditsina, Moscow, pp 48–63Google Scholar
  18. Nanna C, Macmillan H (1960) Neuromuscular blocking action of dihydro-03b2-erythroidine. Arch Int Pharmacodyn Ther 124:445–454Google Scholar
  19. Paton WDM (1959) The effects of muscle relaxants other than muscle relaxation. Anesthesiology 20:454–463CrossRefGoogle Scholar
  20. Rogers AE, Newborne PM (1971) Lasiocarpine: factors influencing its toxicity and effects on liver cell division. Toxicol Appl Pharmacol 18:356–366PubMedCrossRefGoogle Scholar
  21. Salama S, Wright S (1951) Action of calabash curare and related curariform substances on the central nervous system on the cat. Br J Pharmacol 6:459–463Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. A. Kharkevich

There are no affiliations available

Personalised recommendations