Recognition of Physiological Receptors by Anti-Idiotypic Antibodies: Molecular Mimicry of the Ligand or Cross-Reactivity?
The specific binding and physiological modulation of physiological membrane receptors by anti-idiotypic (anti-Id) antibodies has now been described in several systems (reviewed in Strosberg and Schreiber 1984). Two types of explanations have been given for these unexpected interactions. The anti-Id antibody either acts as an internal image of the ligand recognized by both the physiological receptor and the anti-ligand antibody (Jerne 1974, 1984) or, alternatively, there is recognition, by the anti-Id antibodies, of structural homologies shared by the Id-bearing antiligand antibodies and the receptor (Strosberg 1984).
KeywordsNoradrenaline Disulfide Tryptophan Adrenaline Catecholamine
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- Fougereau M, Corbet S, Oilier P, Rocca-Sera J, Roth C, Schoff C, Sommé G, Theze J, Tonnelle C (1985) Structural and genetic basis of the three levels of the idiotypic molecule (Abl, Ab2 and Ab3) in the GAT systems. Ann Immunol (Paris) 136C: 143–156Google Scholar
- Guillet JG, Kaveri SV, Durieu O, Delavier C, Hoebeke J, Strosberg AD (1985) ß-adrenergic agonist activity of a monoclonal anti-idiotypic antibody. Proc Natl Acad Sci USA 82: 1781–1784Google Scholar
- Hoebeke J, Chamat S, Marullo S, Guillet JG, Strosberg AD (1983) Use of the EI A technique in the functional characterization of anti-drug monoclonal antibodies. In: Avrameas S, Druet P, Masseyeff R, Feldmann G (eds) Immunoenzymatic techniques. Elsevier, Amsterdam, pp 307–311Google Scholar
- Jerne NK (1974) Towards a network theory of the immune system. Ann Immunol 125C: 373–389Google Scholar
- Noseworthy JH, Fields BN, Dichter MA, Sobotka C, Pizer E, Perry LL, Nepom JT, Greene MI (1983) Cell receptors for the mammalian reovirus I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus. J Immunol 131: 2533–2538Google Scholar
- Strosberg AD, Schreiber AB (1984) Antibodies to receptors and idiotypes as probes for hormone and neurotransmitter receptor structure and function. In: Greaves HF (ed) Receptors and recognition, Series B, vol 17. Chapman and Hall, London, pp15–38Google Scholar
- Strosberg AD, Chamat S, Guillet JG, Lavaud B, Emorine L, Hoebeke J (1985) Idiotypy of catecholamine binding protiens. Amm Immunol (Paris) 136C:157–168Google Scholar