Recognition of Physiological Receptors by Anti-Idiotypic Antibodies: Molecular Mimicry of the Ligand or Cross-Reactivity?
The specific binding and physiological modulation of physiological membrane receptors by anti-idiotypic (anti-Id) antibodies has now been described in several systems (reviewed in Strosberg and Schreiber 1984). Two types of explanations have been given for these unexpected interactions. The anti-Id antibody either acts as an internal image of the ligand recognized by both the physiological receptor and the anti-ligand antibody (Jerne 1974, 1984) or, alternatively, there is recognition, by the anti-Id antibodies, of structural homologies shared by the Id-bearing antiligand antibodies and the receptor (Strosberg 1984).
KeywordsOpiate Receptor Physiological Receptor Turkey Erythrocyte Mammalian Reovirus Alprenolol Binding
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