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Recognition of Physiological Receptors by Anti-Idiotypic Antibodies: Molecular Mimicry of the Ligand or Cross-Reactivity?

  • A. D. Strosberg
  • J. G. Guillet
  • S. Chamat
  • J. Hoebeke
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 119)

Abstract

The specific binding and physiological modulation of physiological membrane receptors by anti-idiotypic (anti-Id) antibodies has now been described in several systems (reviewed in Strosberg and Schreiber 1984). Two types of explanations have been given for these unexpected interactions. The anti-Id antibody either acts as an internal image of the ligand recognized by both the physiological receptor and the anti-ligand antibody (Jerne 1974, 1984) or, alternatively, there is recognition, by the anti-Id antibodies, of structural homologies shared by the Id-bearing antiligand antibodies and the receptor (Strosberg 1984).

Keywords

Opiate Receptor Physiological Receptor Turkey Erythrocyte Mammalian Reovirus Alprenolol Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1985

Authors and Affiliations

  • A. D. Strosberg
    • 1
  • J. G. Guillet
    • 1
  • S. Chamat
    • 1
  • J. Hoebeke
    • 1
  1. 1.Laboratory of Molecular Immunology, CNRS, Institut Jacques MonodUniversity Paris VIIParis Cedex 05France

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