Recognition of Physiological Receptors by Anti-Idiotypic Antibodies: Molecular Mimicry of the Ligand or Cross-Reactivity?

  • A. D. Strosberg
  • J. G. Guillet
  • S. Chamat
  • J. Hoebeke
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 119)


The specific binding and physiological modulation of physiological membrane receptors by anti-idiotypic (anti-Id) antibodies has now been described in several systems (reviewed in Strosberg and Schreiber 1984). Two types of explanations have been given for these unexpected interactions. The anti-Id antibody either acts as an internal image of the ligand recognized by both the physiological receptor and the anti-ligand antibody (Jerne 1974, 1984) or, alternatively, there is recognition, by the anti-Id antibodies, of structural homologies shared by the Id-bearing antiligand antibodies and the receptor (Strosberg 1984).


Opiate Receptor Physiological Receptor Turkey Erythrocyte Mammalian Reovirus Alprenolol Binding 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1985

Authors and Affiliations

  • A. D. Strosberg
    • 1
  • J. G. Guillet
    • 1
  • S. Chamat
    • 1
  • J. Hoebeke
    • 1
  1. 1.Laboratory of Molecular Immunology, CNRS, Institut Jacques MonodUniversity Paris VIIParis Cedex 05France

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