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Network Regulation of the Immune Response to Bacterial Polysaccharide Antigens

  • Chapter
Images of Biologically Active Structures in the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 119))

Abstract

Protective immunity against encapsulated bacteria can be achieved by eliciting serum antibodies directed against the polysaccharide capsule (Schneerson et al. 1971; Kaijser and Ahlstedt 1977; Egan et al. 1983). In adults and in children over the age of 2 years this can readily be accomplished by the use of polysaccharide vaccines (Makela et al. 1977; Parke et al. 1977; Makela et al. 1980; Vodopija et al. 1983). Infants, however, are unresponsive to most polysaccharide antigens (Smith etal. 1973; Parke et al. 1977; Peltola etal. 1977; Pincus et al. 1982; Kayhty et al. 1984), and a significant proportion of invasive and other serious bacterial infections caused by organisms such as Haemophilus influenzae type b (Hib; Kayhty et al. 1984), Neisseriae meningitidis groups A, B, and C (Band et al. 1983) and Streptococcus pneumoniae (Makela et al. 1980; Douglas and Miles 1984) occurs in this age group. Stimulation of antipolysaccharide antibodies in infants would be enormously important both from the medical point of view and from the inferences that can be drawn regarding our understanding of the mechanisms of neonatal unresponsiveness.

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  1. Division of Bacterial Products, Office of Biologics Research and Review, Center for Drugs and Biologics, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD, 20205, USA

    K. E. Stein

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  1. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski (Director) (Director)

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4058, Basel, Switzerland

    Fritz Melchers

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Stein, K.E. (1985). Network Regulation of the Immune Response to Bacterial Polysaccharide Antigens. In: Koprowski, H., Melchers, F. (eds) Images of Biologically Active Structures in the Immune System. Current Topics in Microbiology and Immunology, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70675-2_5

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