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Molecular Mimicry of Parasite Antigens Using Anti-Idiotypic Antibodies

  • D. L. Sacks
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 119)

Abstract

Current interest in the molecular mimicry of microbial, transplantation, and tumor antigens using anti-idiotypic (anti-Id) antibodies is theoretically grounded in Jerne’s network model (1974), which argues the following: The antigen- combining site, designated paratope, of every antibody molecule recognizes the idiotope of some other antibody molecule. This requires that external (non- immunoglobulin) epitopes and internal idiotopes must be largely overlapping, since they are each recognized by the same set of paratopes. Therefore, for each foreign epitope there must be an idiotope which bears its internal image. In order to obtain antibody molecules which bear epitope-related conformational structures, the strategy has been to immunize with antibody molecules, designated Abl, expressing a paratope for a given epitope, with the intent of inducing a population of antibodies, designated Ab2, some of which share with the epitope a complementary structure to the Abl paratope (Fig. 1). This subpo- pulation of paratope-induced, anti-Abl antibodies has been termed Ab2β, to distinguish it from the more classically considered population pf anti-Id antibodies, termed Ab2α, which are induced by Abl idiotopes and therefore lack any epitope-related structures (Jerne et al. 1982). Assuming that the interaction with receptors through either their paratopes or idiotopes can provide identical signals to the cells which bear them, then both Ab2 populations should be induced by Abl.

Keywords

Molecular Mimicry Trypanosoma Cruzi Parasite Antigen Carbohydrate Epitope Variant Surface Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bluestone J A, Epstein SL, Ozato K, Sharrow SO, Sachs DH (1981) Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen. J Exp Med 154: 1305PubMedCrossRefGoogle Scholar
  2. Bona C, Heber-Katz E, Paul WE (1981) Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti antibodies and to the activation of silent clones. J Exp Med 153: 951PubMedCrossRefGoogle Scholar
  3. Cazenave PA (1977) Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits. Proc Natl Acad Sci USA 77: 5122CrossRefGoogle Scholar
  4. Epstein SL, Masakowski VR, Sharrow SO, Bluestone J A, Ozato K, Sachs DH (1982) Idiotypes of anti-IA antibodies. II. Effects of in vivo treatment with xenogeneic anti-idiotype. J Immunol 129: 1545PubMedGoogle Scholar
  5. Francotte M, Urbain J (1984) Induction of anti-TMV antibodies in mice by rabbit anti-idiotype antibodies. J Exp Med 160: 1485PubMedCrossRefGoogle Scholar
  6. Jerne NK (1974) Towards a network theory of the immune system. Ann Immunol (Paris) 125c: 373Google Scholar
  7. Jerne NK, Roland J, Caznave PA (1982) Recurrent idiotypes and Internal images. EMBO 1: 234Google Scholar
  8. Kennedy RC, Ionescu-Matiu RC, Sanchez Y, Dreesman GR (1983 a) Detection of interspecies cross-reactions associated with antibodies to Hepatitis B surface antigen. Eur J Immunol 13: 232CrossRefGoogle Scholar
  9. Kennedy RC, Adler-Strothz K, Henkel RD, Sanchez Y, Melnick JL, Dreesman GR (1983b) Immune response to hepatitis B surface antigen: and enhancement by prior injection of antibodies to the idiotype. Science 221: 835CrossRefGoogle Scholar
  10. Kirchoff LV, Hieny S, Shriver GM, Snary D, Sher A (1984) Cryptic epitope explains the failure of monoclonal antibody to bind to certain isolates of Trypanosoma cruzi. J Immunol 133: 2731Google Scholar
  11. Nisonoff A, Lamoyi E (1981) Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies; possible application to vaccine production. Clin Immunol Immuno- pathol 21: 397CrossRefGoogle Scholar
  12. Paul WE, Bona C (1982) Regulatory idiotopes and immune networks: a hypothesis. Immunol Today 3: 230CrossRefGoogle Scholar
  13. Reagan KJ, Wunner WH, Wiktor I J, Koprowski H (1983) Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein. J Virol 48: 660PubMedGoogle Scholar
  14. Sachs DH (1981) Genetic control of idiotype expression. In: Progress in immunology IV, J. Dausset, ed. Academic, LondonGoogle Scholar
  15. Sacks DL, Sher A (1983) Evidence that anti-idiotype induced immunity to experimental African trypanosomiasis is genetically restricted and requires recognition of combining site-related idiotopes. J Immunol 131: 1511PubMedGoogle Scholar
  16. Sacks DL, Esser KM, Sher A (1982) Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies. J Exp Med 155: 1108PubMedCrossRefGoogle Scholar
  17. Sacks DL, Kelsoe GH, Sacks DH (1983) Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity. Springer Semin Immunopathol 6: 79PubMedCrossRefGoogle Scholar
  18. Sher A, Snary D (1982) Specific inhibition of the morphogenesis of Trypanosoma cruzi by a monoclonal antibody. Nature (Lond) 300: 639CrossRefGoogle Scholar
  19. Snary D (1983) Cell surface glycoproteins of Trypanosoma cruzi: protective immunity in mice and antibody levels in human chagasic sera. Trans R Soc Trop Med Hyg 77: 126PubMedCrossRefGoogle Scholar
  20. Snary D, Ferguson MAJ, Scott MT, Allan AK (1981) Cell surface antigens of Trypanosoma cruzi: use of monoclonal antibodies to identify and isolate an epimastigote specific glycoprotein. Mol Biochem Parasitol 3: 343PubMedCrossRefGoogle Scholar
  21. Stein K, Soderstrom T (1984) Neonatal administration of idiotype or anti-idiotype primes for protection against E. coli K13 infection in mice. J Exp Med 160: 1001PubMedCrossRefGoogle Scholar
  22. Takemori T, Tesch H, Reth M, Rajewski K (1982) The immune response against anti-idiotope antibodies I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire. Eur J Immunol 12: 1040Google Scholar
  23. Trenkner E, Riblet R (1975) Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies. J Exp Med 142: 1121PubMedCrossRefGoogle Scholar
  24. Urbain J, Wikler M, Franssen JD, Collignon C (1977) Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies. Proc Natl Acad Sci USA 74: 5126PubMedCrossRefGoogle Scholar
  25. Urbain J, Slaoui M, Madame B, Leo O (1984) Idiotypy and internal images. In: Idiotypy in biology and medicine, H. Kohler, J. Urbain, P.A. Cazenave, eds. Academic, LondonGoogle Scholar
  26. Uytdehaag F, Osterhaus A (1985) Induction of neutralizing antibody in mice against polio virus type II with monoclonal anti-idiotypic antibody. J Immunol 134: 1225PubMedGoogle Scholar
  27. Wikler M, Franssen JD, Collignon C, Leo O, Mariane B, Van de Walle P, De Groote D, Urbain J (1979) Idiotypic regulation of the immune system: common idiotypic specificities between idio- types and antibodies raised against anti-idiotypic antibodies in rabbits. J Exp Med 150: 184CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1985

Authors and Affiliations

  • D. L. Sacks
    • 1
  1. 1.Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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