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Vaccines from Monoclonal Anti-Idiotypic Antibody: Poliovirus Infection as a Model

  • Chapter
Images of Biologically Active Structures in the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 119))

Abstract

Manipulation of the immune system by “foreign” substances, i.e., the induction of protective immune response against certain pathogens by vaccination has proven to be of great practical value in contributing to the control of infectious diseases in man and animals. In the case of smallpox, it has even led to the eradication of the disease. However, for a number of infectious diseases there are still major problems in the production of effective vaccines. This is partly due to the fact that antigens cannot be generated in sufficient amounts or in the proper immunogenic form. Among the different approaches to overcoming these problems (reviewed by Arnon etal. 1983 and Norrby 1983) the use of the elements of the immune system itself, i.e., anti-idiotypic antibodies has recently attracted great attention (see e.g. Nisonoff and Lamoyi 1981 and Zoler 1984). In light of present idiotype (Id) research, it must be considered possible to administer anti-Id antibody (Ab2) exogenously to replace antigen for the induction of specific immune response (see for review, Rajewski and Takemori 1983 and Sacks and Sher 1983).

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Authors and Affiliations

  1. The National Institute of Public Health and Environmental Hygiene, P.O. Box 1, NL-3720, BA Bilthoven, Netherlands

    F. G. C. M. UytdeHaag & A. D. M. E. Osterhaus

Authors
  1. F. G. C. M. UytdeHaag
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  2. A. D. M. E. Osterhaus
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Editors and Affiliations

  1. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski (Director) (Director)

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4058, Basel, Switzerland

    Fritz Melchers

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© 1985 Springer-Verlag Berlin · Heidelberg

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UytdeHaag, F.G.C.M., Osterhaus, A.D.M.E. (1985). Vaccines from Monoclonal Anti-Idiotypic Antibody: Poliovirus Infection as a Model. In: Koprowski, H., Melchers, F. (eds) Images of Biologically Active Structures in the Immune System. Current Topics in Microbiology and Immunology, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70675-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-70675-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70677-6

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