Abstract
Muscarinic antagonists are widely used in clinical medicine as inhibitors of secretory and motor functions of the gastrointestinal (GI) tract. Atropine as a potent muscarinic inhibitor produces considerable side effects on the heart, accommodation, and saliva secretion. Pirenzepine, a tricyclic compound with muscarinic-1 (M1)-receptor antagonist properties, varies in its affinity for the different subclasses of muscarinic receptors (Hammer et al. 1980). Besides a reduction in gastric volume secretion, there are contradictatory results as far as the effect on lower esophageal sphincter pressure (LESP) is concerned (Jaup et al. 1982; Malhotra et al. 1983). In accordance with the finding of various muscarinic receptors on smooth muscle cells and myenteric neurons within the GI tract (Goyal and Rattan 1978; Fox et al. 1983), a different effect on GI motility may be observed with a selective M1-antagonist, as compared with the less specific actions of atropine.
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© 1985 Springer-Verlag Berlin Heidelberg
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Lederer, P.C., Thiemann, R., Ellermann, A., Radeck, J., Lux, G. (1985). Muscarinic M1-Receptor-Antagonists in Health and Disease. In: Lux, G., Daniel, E.E. (eds) Muscarinic Receptor Subtypes in the GI Tract. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70668-4_9
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DOI: https://doi.org/10.1007/978-3-642-70668-4_9
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